Anti-Leukotriene A4 Hydrolase Antibody

Cat: 50268-RP01
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Anti-Leukotriene A4 Hydrolase Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Leukotriene A4 Hydrolase Antibody
Validated applications
Species reactivity
Reacts with: Mouse
Mouse Leukotriene A4 Hydrolase
Recombinant Mouse LTA4H protein (Catalog#50268-M08B)
Produced in rabbits immunized with purified, recombinant Mouse LTA4H / LTA4 Hydrolase (rM LTA4H; Catalog#50268-M08B; NP_032543.2; Met 1-Asp 611). Total IgG was purified by Protein A affinity chromatography.
Polyclonal Rabbit IgG
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Leukotriene A4 Hydrolase Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Leukotriene A4 Hydrolase Antibody Alternative Names
Anti-Lta4h Antibody
Leukotriene A4 Hydrolase Background Information

Leukotriene A-4 hydrolase, also known as LTA-4 hydrolase, Leukotriene A (4) hydrolase, LTA4H and LTA4, is cytoplasm protein which belongs to the peptidase M1 family. LTA4H hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4). This enzyme also has some peptidase activity. The leukotrienes (LTs) are a class of structurally related lipid mediators involved in the development and maintenance of inflammatory and allergic reactions. In the biosynthesis of LTs, arachidonic acid was converted into the unstable intermediate epoxide LTA4, which may in turn be conjugated with glutathione to form the spasmogenic LTC4, or hydrolyzed into the proinflammatory lipid mediator LTB4 in a reaction catalyzed by Leukotriene A4 hydrolase (LTA4H). LTB4 is a classical chemoattractant of human neutrophils and triggers adherence and aggregation of leukocytes to vascular endothelium, and also modulates immune responses. As a bifunctional zinc metalloenzyme, LTA4H also exhibits an anion-dependant arginyl aminopeptidase activity of high efficiency and specificity in addition to its epoxide hydrolase activity. LTA4H is regarded as a therapeutic target for inflammation.

Full Name
leukotriene A4 hydrolase
  • Mancini, JA. et al.,1995, Eur. J. Biochem. 231: 65-71.
  • Orning, L. et al., 1994, J. Biol. Chem. 269: 11269-73.
  • Rudberg, PC. et al., 2004, J. Biol. Chem. 279: 27376-82.
  • Qiu, H. et al., 2006, Proc. Natl. Acad. Sci. USA. 103: 8161-6.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Leukotriene A4 Hydrolase Antibody Rabbit Polyclonal WB,ELISA,IP 50268-RP02
    Anti-Leukotriene A4 Hydrolase Antibody Rabbit Monoclonal ELISA 10276-R455
    Anti-Leukotriene A4 Hydrolase Antibody Rabbit Polyclonal WB,ELISA,IP 10276-RP02
    Anti-Leukotriene A4 Hydrolase Antibody Rabbit Monoclonal WB,ELISA,ICC/IF,IF,IP 10276-R201
    Anti-Leukotriene A4 Hydrolase Antibody Rabbit Monoclonal ELISA 10276-R457
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