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Leukotriene A4 Hydrolase / LTA4H Antibody, Rabbit MAb
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Leukotriene A4 Hydrolase / LTA4H Antibody, Rabbit MAb PDF Download

Catalog   Size (Price) Quantity In Stock Operation
10276-R455  

YES   
 

Primary antibody | Secondary antibody | Tag antibody | Isotype control antibody | Loading control antibody | Antibody Purification

Leukotriene A4 Hydrolase / LTA4H Antibody Datasheet

  Order or Inquire for Leukotriene A4 Hydrolase / LTA4H Antibody product Quality antibodies Antibody production services
  Detection limit is 0.0049 ng/well in ELISA
 

Leukotriene A4 Hydrolase / LTA4H Antibody Product Information

Immunogen :

Recombinant Human Leukotriene A4 Hydrolase / LTA4H protein (Catalog#10276-H08B)

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )

Clone ID :

455

Ig Type :

Rabbit IgG

Formulation : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
Preparation :

This antibody was obtained from a rabbit immunized with purified, recombinant Human Leukotriene A4 Hydrolase / LTA4H (rh Leukotriene A4 Hydrolase / LTA4H; Catalog#10276-H08B; NP_000886.1; Met1-Asp611).

Leukotriene A4 Hydrolase / LTA4H Antibody Usage Guide

Specificity :

Human Leukotriene A4 Hydrolase / LTA4H

Direct ELISA : This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human LTA4H. The detection limit for Human LTA4H is approximately 0.0049 ng/well.
Storage : This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Leukotriene A4 Hydrolase / LTA4H Antibody Related Products & Topics

Related Areas:

Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>Leukotriene A4 Hydrolase/LTA4H

Enzyme>>Lipid Metabolism Enzymes>>Leukotriene A4 Hydrolase/LTA4H

Cardiovascular>>Lipid Metabolism>>Lipid Metabolism Enzymes>>Leukotriene A4 Hydrolase/LTA4H

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
Leukotriene A4 Hydrolase/LTA4H Human Leukotriene A4 Hydrolase/LTA4H Protein, Recombinant 10276-H08B
Leukotriene A4 Hydrolase/LTA4H Mouse Leukotriene A4 Hydrolase/LTA4H Protein, Recombinant 50268-M08B

Antibodies:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
Leukotriene A4 Hydrolase/LTA4H
WB, ELISA Leukotriene A4 Hydrolase/LTA4H Antibody, Rabbit PAb (Antigen Affinity Purified) 10276-RP02
Human
Leukotriene A4 Hydrolase/LTA4H
WB, ELISA Leukotriene A4 Hydrolase / LTA4H Antibody 10276-R201
Human
Leukotriene A4 Hydrolase/LTA4H
ELISA Leukotriene A4 Hydrolase / LTA4H Antibody 10276-R455
Human
Leukotriene A4 Hydrolase/LTA4H
ELISA Leukotriene A4 Hydrolase / LTA4H Antibody 10276-R457
Mouse
Leukotriene A4 Hydrolase/LTA4H
WB, ELISA Leukotriene A4 Hydrolase/LTA4H Antibody, Rabbit PAb 50268-RP01
Mouse
Leukotriene A4 Hydrolase/LTA4H
WB, ELISA Leukotriene A4 Hydrolase/LTA4H Antibody, Rabbit PAb (Antigen Affinity Purified) 50268-RP02

Leukotriene A4 Hydrolase / LTA4H Antibody Background


The leukotrienes (LTs) are a class of structurally related lipid mediators involved in the development and maintenance of inflammatory and allergic reactions. In the biosynthesis of LTs, arachidonic acid was converted into the unstable intermediate epoxide LTA4, which may in turn be conjugated with glutathione to form the spasmogenic LTC4, or hydrolyzed into the proinflammatory lipid mediator LTB4 in a reaction catalyzed by Leukotriene A4 hydrolase (LTA4H). LTB4 is a classical chemoattractant of human neutrophils and triggers adherence and aggregation of leukocytes to vascular endothelium, and also modulates immune responses. As a bifunctional zinc metalloenzyme, LTA4H also exhibits an anion-dependant arginyl aminopeptidase activity of high efficiency and specificity in addition to its epoxide hydrolase activity. LTA4H is thus regarded as a therapeutic target for inflammation.

References

  1. Mancini, J.A. and Evans. J.F. 1995, Eur. J. Biochem. 231: 65-71.
  2. Orning, L. et al., 1994, J. Biol. Chem. 269: 11269-11273.
  3. Rudberg, P.C. et al., 2004, J. Biol. Chem. 279: 27376-27382.
  4. Qiu, H. et al., 2006, Proc. Natl. Acad. Sci. USA. 103: 8161-8166.
 
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