Leukemia Therapeutic Targets

Protein Name	Alternative Names	BioChemical Class / Role	Products (Cat NO)
			Protein	Antibody	Gene cDNA clones
CD116/GM-CSFR	Csfgmra, GM-CSF-Ra, Csf2ra	The granulocyte macrophage colony-stimulating factor receptor (GM-CSFR) also known as CD116, is a low affinity receptor for granulocyte macrophage colony-stimulating factor (GM-CSF), which stimulates the production of white blood cells. The CD116/GM-CSFR is a heterodimer composed of at least two different subunits, an α chain, and a β chain which is also present in the receptors for IL-3 and IL-5.	10701-H02H, 10701-H08H		HG10701-M
Mcl-1					HG10240-M
PLK1/PLK-1	STPK13	Serine/threonine-protein kinase PLK1, also known as Polo-like kinase 1, PLK1 and STPK13, is a member protein kinase superfamily and CDC5/Polo subfamily. Studies have shown that the loss of PLK1 expression can induce pro-apoptotic pathways and inhibit growth. Moreover, PLK1 seems to be involved in the tumor suppressor p53 related pathways. Evidence suggests that PLK1 can inhibit transactivation and pro-apoptotic functions of p53 function by physical interaction and phosphorylation.	10676-H07B		HG10676-M
CDK9/CDC2L4					HG10907-M
Leukotriene A4 Hydrolase/LTA4H		As a bifunctional zinc metalloenzyme, LTA4H also exhibits an anion-dependant arginyl aminopeptidase activity of high efficiency and specificity in addition to its epoxide hydrolase activity. This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds (ether hydrolases). LTA4H participates in arachidonic acid metabolism, and is regarded as a therapeutic target for inflammation.	10276-H08B		HG10276-M, MG50268-M
PKC alpha					HG10026-M
JAK2					HG11198-M
VEGFR1/FLT-1	FLT1, FLT				HG10136-M
VEGFR2/Flk-1/CD309	KDR, VEGFR	A vascular endothelial growth factor (VEGF) receptor.	10012-H02H		HG10012-M
VEGFR3/FLT-4	FLT41, LMPH1A, PCL	VEGFR3 (FLT-4), together with the other two members VEGFR1 (FLT-1) and VEGF R2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs).	10806-H02H, 10806-H08H	10806-MM02, 10806-MM03, 10806-RP01, 10806-RP04	HG10806-M
MMP-1/MMP1	CLG, CLGN				HG10532-M
MMP-2/MMP2	CLG4, CLG4A, MMP-II, MONA, TBE-1				HG10082-M
MMP-3/MMP3	CHDS6, MGC126102, MGC126103, MGC126104, MMP-3, SL-1, STMY, STMY1, STR1				HG10467-M
MMP-7/MMP7	MPSL1, PUMP-1	MMP7, also referred to as matrilysin, is the smallest member of the MMP family and differs from other MMP members in that it lacks the C-terminal hemopexin-like domain. This enzyme serves essential functions in both innate defense and wound healing, and appears to be one of the most important MMPs in human colon cancers. In addition, matrilysin is also identified as a mediator of pulmonary fibrosis and a potential therapeutic target.	10277-H01H		HG10277-M
MMP-8/MMP8	CLG1, HNC, PMNL-CL				HG10254-M
MMP-9/MMP9	CLG4B, GELB, MANDP2	MMP9, also known as 92-kDa gelatinase B/type IV collagenase, is secreted from neutrophils, macrophages. This enzyme degrades various substrates including gelatin, collagen types IV and V, and elastin. MMP9 is involved in a variety of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis, and be regarded as a potential therapeutic target.	10327-H08H, 10327-HNAE	10327-MM01, 10327-MM02, 10327-RM04, 10327-RM05, 10327-RP03, 10327-RP06	HG10327-M
MMP-10/MMP10	SL-2, STMY2				HG10249-M
MMP-12/MMP12	HME, MGC138506, MME				HG10266-M
MMP-14/MMP14	MMP-X1,  MTMMP1,  MT1-MMP				HG10741-M
CDKN1A	CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1				HG11108-M
SGK1/SGK					HG10543-M, MG50278-M