Leukemia Inhibitory Factor (LIF)

Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the IL-6 family of cytokines. It's involved in growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation. LIF has potent proinflammatory property, being the inducer of the acute phase protein synthesis and affecting the cell recruitment into the area of damage or inflammation. LIF is also one of the cytokines that are capable to regulate the differentiation of embryonic stem cells, hematopoietic and neuronal cells. LIF binds to the specific LIF receptor (LIFR-α) which forms a heterodimer with a specific subunit common to all members of that family of receptors, the GP130 signal transducing subunit. This leads to activation of the JAK/STAT and MAPK cascades. Due to its polyfunctional activities, LIF is involved in the pathogenic events and development of many diseases of various origin.

Leukemia Inhibitory Factor (LIF) Related Areas

Stem Cell>>Embryonic Stem Cell (ESC)>>Embryonic Cell Lineage Marker>> LIF

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-6 Family & Receptor>>LIF

Leukemia Inhibitory Factor (LIF) Alternative Names

RP23-329P17.1,OTTMUSP00000005253,d factor [Mus musculus]

Summaries for Leukemia Inhibitory Factor (LIF)

Entrez Gene summary for Leukemia Inhibitory Factor (LIF):

The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

OMIM - description for Leukemia Inhibitory Factor (LIF):

 

Wikipedia summary for Leukemia Inhibitory Factor (LIF):

Leukemia inhibitory factor, or LIF, an interleukin 6 class cytokine, is a protein in cells that affects cell growth by inhibiting differentiation. However, with use of Serem Replacement the ESCs will differentiate.

Human Leukemia Inhibitory Factor (LIF) Protein General Information

 

• Protein names: Recommended name: Leukemia inhibitory. factor Short name = LIF
• Sequence length: 202 AA.
• Domain: Signal
• Pharmaceutical use: In phase II clinical trial. The drug is being developed by Amrad to assist embryo implantation in women who have failed to become pregnant despite assisted reproductive technologies (ART).
• Sequence similarities: Belongs to the LIF/OSM family.
• Subcellular location: Secreted.

General information above from UniProt

Function for Leukemia Inhibitory Factor (LIF) Protein

UniProtKB:

LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.

Genatlas:

• Leukemia Inhibitory Factor (LIF) is a cholinergic neuronal differentiation factor
• Leukemia Inhibitory Factor (LIF) induces macrophage differentiation and in conjunction with BMP2 acting in synergy on primary fetal neural progenitor cells to induce astrocytes
• Leukemia Inhibitory Factor (LIF) induces multi-lineage differentiation of adult stem-like cells in kidney via cadherin 16
• Leukemia Inhibitory Factor (LIF) plays a central role in the control of uterine implantation
• Leukemia Inhibitory Factor (LIF) reduces neurogenesis in the olfactory bulb and subventricular zone by acting directly on neural stem cells and promote neural stem cells self-renewal, preventing the emergence of more differentiated cell types
• Leukemia Inhibitory Factor (LIF) is involved in the control of osteoclast survival and size
• with IL11 regulated endometrial epithelial cell adhesion (Marwood 2009)
• potential role for LIF in the melanoma-induced bone metastasis possibly through the stimulation of osteoclastogenesis (Maruta 2009)
• Leukemia Inhibitory Factor (LIF) inhibits osteoblast development at least in part by stimulating high molecular weight HA synthesis through HAS2 (Falconi 2007)
• Leukemia Inhibitory Factor (LIF) plays a role in mesenchymal stem cells mediated immunosuppression (Nasef 2008)
• Leukemia Inhibitory Factor (LIF) might be one of the reasons that cause patients with salpingitis to be more susceptible to tubal pregnancy and might be involved in the implantation process of tubal pregnancy (JI 2009)
• With CNTF, LEP, IL6, Leukemia Inhibitory Factor (LIF)  participates to the complex control of the reproductive function by affecting the development and function of the hypothalamus-pituitary system at different ontogenic times and anatomical sites