Leptin Receptor Protein (LEPR, CD295 Protein)

Cluster of Differentiation 295

Leptin Receptor Products

Leptin Receptor Protein, Recombinant

Molecule	Species	Description	Cat. No
Leptin Receptor/CD295	Human	Leptin Receptor/CD295/Fc ProteinRecombinant	10322-H03H
Leptin Receptor/CD295	Human	Leptin Receptor/CD295 ProteinRecombinant	10322-H08H

  10322-H03H:  Immobilized human Leptin at 1.25 µg/ml (100 µl/well) can bind human Leptin receptor with a linear range of 0.032-4.0 µg/ml. Measured by its binding ability in a functional ELISA.

  10322-H08H:  Immobilized human Leptin at 5 µg/ml (100 µl/well) can bind human Leptin receptor with a linear range of 0.032-4.0 µg/ml. Measured by its binding ability in a functional ELISA.

Leptin Receptor Antibody

Molecule	Application	Description	Cat. No
Human	WB, ELISA	Mouse Monoclonal Antibody	10322-MM05
Human Leptin Receptor/CD295	WB, ELISA	Leptin Receptor / CD295 / LEPR Antibody (Antigen Affinity Purified)	10322-RP02

Leptin Receptor cDNA Clone

Molecule	Species	Description	Cat. No
Leptin Receptor/CD295	Human	Homo sapiens Leptin Receptor/CD295 transcript variant 1 cDNA Clone(NM_002303.3)	HG10322-M

Leptin Receptor Related Areas

Cardiovascular>>Red Blood Cell>>Leptin Receptor/CD295

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>Leptin Receptor/CD295

Immunology>>Cytokine & Receptor>>Interleukin & Receptor >>IL-6 Family & Receptor>>Leptin Receptor/CD295

Immunology>>Cluster of Differentiation>>Other>>Leptin Receptor/CD295

Cardiovascular>>Lipid Metabolism>>Leptin Receptor/CD295

Leptin Receptor Alternative Names

LEPR, CD295, OBR [Homo sapiens]

Lepr, RP23-31K16.2, LEPROT, Leprb, MGC105189, Modb1, OB-RGRP, Obr, db, diabetes, obese-like, obl [Mus musculus]

Leptin Receptor Background

Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Leptin Receptor/CD295 is a transmembrane catalytic receptors found on NPY/AgRP and alpha-MSH/CART neurons in hypothalamic nuclei. Leptin receptors (Ob-Rs) are coded for by one human gene that produces six different isoforms; Ob-Ra - Ob-Rf. Ob-Rs exist as constitutive dimers at physiological expression levels. Only the Ob-Rb isoform can transduce intracellular signals and does so through activation of the JAK2/STAT3, PI 3-K and MAPK signaling cascades. Activation of Ob-Rs mediates transcriptional regulation of the hypothalamic melanocortin pathway and downregulates endocannabinoid expression. Leptin acts via leptin receptors. Leptin resistance has been proposed as a pathophysiological mechanism of obesity. In obese individuals, Ob-Ra (which is involved in active transport of leptin across the blood-brain barrier) expression is downregulated and the individual may be unresponsive to leptin signals. Ob-R antagonists are of great interest in the development of pharmacological treatments for obesity. Mutations in Leptin Receptor/CD295 have been associated with obesity and pituitary dysfunction.

Leptin Receptor Related Studies

1. Heshka JT, et al. (2001) A role for dietary fat in leptin receptor, OB-Rb, function. Life Sci. 69 (9): 987-1003.
2. Chen H, et al (1996) Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 84 (3): 491-5.
3. Bjørbaek C, et al. (1998) Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem. 272 (51): 32686-95.