Anti-Leptin Receptor Antibody

Cat: 10322-RP02
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Anti-Leptin Receptor Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Leptin Receptor Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Leptin Receptor
Immunogen
Recombinant Human Leptin Receptor / CD295 / LEPR protein (Catalog#10322-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human Leptin Receptor / CD295 / LEPR (rh Leptin Receptor / CD295 / LEPR; Catalog#10322-H08H; NP_002294.2; Met 1-Asp 839). Leptin Receptor / CD295 / LEPR specific IgG was purified by Human Leptin Receptor / CD295 / LEPR affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Leptin Receptor Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Leptin Receptor Antibody Alternative Names
Anti-CD295 Antibody;Anti-LEP-R Antibody;Anti-LEPRD Antibody;Anti-OB-R Antibody;Anti-OBR Antibody
Leptin Receptor Background Information

Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Leptin Receptor/CD295 is a transmembrane catalytic receptors found on NPY/AgRP and alpha-MSH/CART neurons in hypothalamic nuclei. Leptin receptors (Ob-Rs) are coded for by one human gene that produces six different isoforms; Ob-Ra - Ob-Rf. Ob-Rs exist as constitutive dimers at physiological expression levels. Only the Ob-Rb isoform can transduce intracellular signals and does so through activation of the JAK2/STAT3, PI 3-K and MAPK signaling cascades. Activation of Ob-Rs mediates transcriptional regulation of the hypothalamic melanocortin pathway and downregulates endocannabinoid expression. Leptin acts via leptin receptors. Leptin resistance has been proposed as a pathophysiological mechanism of obesity. In obese individuals, Ob-Ra (which is involved in active transport of leptin across the blood-brain barrier) expression is downregulated and the individual may be unresponsive to leptin signals. Ob-R antagonists are of great interest in the development of pharmacological treatments for obesity. Mutations in Leptin Receptor/CD295 have been associated with obesity and pituitary dysfunction.

Full Name
leptin receptor
References
  • Heshka JT, et al. (2001) A role for dietary fat in leptin receptor, OB-Rb, function. Life Sci. 69 (9): 987-1003.
  • Chen H, et al (1996) Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 84 (3): 491-5.
  • Bjrbaek C, et al. (1998) Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem. 272 (51): 32686-95.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Leptin Receptor Antibody Rabbit Polyclonal WB,IHC-P 102018-T40
    Anti-Leptin Receptor Antibody Rabbit Polyclonal IHC-P 102018-T08
    Anti-Leptin Receptor Antibody Rabbit Monoclonal ELISA 10322-R003
    Anti-Leptin Receptor Antibody Mouse Monoclonal ELISA 10322-MM16
    Anti-Leptin Receptor Antibody Rabbit Polyclonal ELISA 10322-RP01
    Anti-Leptin Receptor Antibody Mouse Monoclonal ELISA 10322-MM05
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