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Leptin Receptor/CD295  ELISA Products

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    Leptin Receptor/CD295 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    Leptin Receptor/CD295 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    Leptin Receptor/CD295 Summary & Protein Information

    Leptin Receptor/CD295 Related Information

    Leptin Receptor/CD295 Background

    Gene Summary: The protein encoded by this LEPR gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This leptin receptor protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this LEPR gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).
    General information above from NCBI
    Subunit structure: On leptin stimulation, homodimerizes. The phosphorylated receptor binds a number of SH2 domain-containing proteins such as STAT3, PTPN11, and SOCS3 (By similarity). Interaction with SOCS3 inhibits LRb signaling (By similarity). {ECO:0000250}.
    Domain: The cytoplasmic domain may be essential for intracellular signal transduction by activation of JAK tyrosine kinase and STATs.; The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; The box 1 motif is required for JAK interaction and/or activation.
    Subcellular location: Cell membrane; Single-pass type I membrane protein.; Isoform E: Secreted {ECO:0000305}.
    Tissue specificity: Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.
    Post-translational: On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3 (By similarity). Phosphorylation on Tyr-1141 is required for STAT3 binding/activation. {ECO:0000250}.
    Involvement in disease: DISEASE: Leptin receptor deficiency (LEPRD) [MIM:614963]: A rare disease characterized by normal levels of serum leptin, hyperphagia and severe obesity from an early age. Additional features include alterations in immune function, and delayed puberty due to hypogonadotropic hypogonadism. {ECO:0000269|PubMed:9537324}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Sequence similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily. {ECO:0000305}.; Contains 4 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.; Contains 1 Ig-like (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Leptin Receptor/CD295 is a transmembrane catalytic receptors found on NPY/AgRP and alpha-MSH/CART neurons in hypothalamic nuclei. Leptin receptors (Ob-Rs) are coded for by one human gene that produces six different isoforms; Ob-Ra - Ob-Rf. Ob-Rs exist as constitutive dimers at physiological expression levels. Only the Ob-Rb isoform can transduce intracellular signals and does so through activation of the JAK2/STAT3, PI 3-K and MAPK signaling cascades. Activation of Ob-Rs mediates transcriptional regulation of the hypothalamic melanocortin pathway and downregulates endocannabinoid expression. Leptin acts via leptin receptors. Leptin resistance has been proposed as a pathophysiological mechanism of obesity. In obese individuals, Ob-Ra (which is involved in active transport of leptin across the blood-brain barrier) expression is downregulated and the individual may be unresponsive to leptin signals. Ob-R antagonists are of great interest in the development of pharmacological treatments for obesity. Mutations in Leptin Receptor/CD295 have been associated with obesity and pituitary dysfunction.

    Leptin Receptor/CD295 Alternative Name

    OBR,OB-R,CD295,LEP-R,LEPRD, [homo-sapiens]
    CD295,LEPR,OBR, [human]
    db,diabetes,Lepr,Leprb,LEPROT,MGC105189,Modb1,obese-like,obl,Obr,OB-RGRP,RP23-31K16.2, [mouse]
    db,Obr,obl,Leprb,Modb1,LEPROT,OB-RGRP,diabetes,obese-like, [mus-musculus]

    Leptin Receptor/CD295 Related Studies

  • Heshka JT, et al. (2001) A role for dietary fat in leptin receptor, OB-Rb, function. Life Sci. 69 (9): 987-1003.
  • Chen H, et al (1996) Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 84 (3): 491-5.
  • Bjrbaek C, et al. (1998) Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem. 272 (51): 32686-95.
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