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Leptin Protein & Antibody

Leptin Products

Leptin Products

Leptin Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
Leptin Human Leptin Protein, Recombinant 10221-HNAE

  10221-HNAE:

1. Immobilized human Leptin at 1.25 µg/ml (100 µl/well) can bind human Leptin receptor Fc chimera with a linear range of 0.032-4.0 µg/ml. Measured by its binding ability in a functional ELISA.

2. Immobilized human Leptin at 5 µg/ml (100µl/well) can bind human Leptin receptor his with a linear range of 0.032-4.0 µg/ml. Measured by its binding ability in a functional ELISA.

Leptin Antibody

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
Leptin
WB, ELISA Leptin Antibody, Mouse MAb 10221-MM01
Human
Leptin
WB, ELISA Rabbit Polyclonal Antibody 10221-RP01
Human
Leptin
WB, ELISA Rabbit Polyclonal Antibody 10221-RP02

Leptin cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
Leptin Human Homo sapiens Leptin cDNA Clone(NM_000230.2) HG10221-M
Leptin Mouse Mus musculus Leptin cDNA Clone MG50442-M

Leptin Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>Leptin

Cancer>>Cancer Biomarkers>>Leptin

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-6 Family & Receptor>>Leptin

Cardiovascular>>Lipid Metabolism>>Leptin

Leptin Alternative Names

Leptin, LEP, OB, OBS, FLJ94114 [Homo sapiens]

Leptin, Lep, ob, obese [Mus musculus]

Leptin Background

Leptin is one of the most important hormones secreted by adipocytes, as an adipokine that modulates multiple functions including energy homeostasis, thermoregulation, bone metabolism, endocrine and pro-inflammatory immune responses. The circulating leptin levels serve as a gauge of energy stores, thereby directing the regulation of energy homeostasis, neuroendocrine function, and metabolism. Recent studies suggest that leptin is physiologically more important as an indicator of energy deficiency, rather than energy excess, and may mediate adaptation by driving increased food intake and directing neuroendocrine function to converse energy, such as inducing hypothalamic hypogonadism to prevent fertilization. One of these functions is the connection between nutritional status and immune competence. The adipocyte-derived hormone Leptin has been shown to regulate the immune response, innate and adaptive response, both in normal and pathological conditions. Thus, Leptin is a mediator of the inflammatory response. Leptin has a dual effect on bone, acting by two independent mechanisms. As a signal molecule with growth factor characteristics, leptin is able to stimulate osteoblastic cells and to inhibit osteoclast formation and activity, thus promoting osteogenesis. However, as a molecule which stimulates sympathetic neurons in the hypothalamus, leptin indirectly inhibits bone formation. This inhibitory effect of leptin mediated by activation of sympathetic nervous system can be abrogated by application of blood pressure-reducing beta-blockers, which also inhibit receptors of hypothalamic adrenergic neurons. Leptin appears to regulate a number of features defining Alzheimer's disease (AD) at the molecular and physiological level. Leptin can stimulate mitogenic and angiogenic processes in peripheral organs. Because leptin levels are elevated in obese individuals and excess body weight has been shown to increase breast cancer risk in postmenopausal women. Furthermore, a recent report clearly shows that targeting leptin signaling may reduce mammary carcinogenesis.

Leptin Related Studies

  1. Surmacz E. (2007) Obesity hormone leptin: a new target in breast cancer? Breast Cancer Res. 9(1): 301.
  2. WÅ‚odarski K, et al. (2009) Leptin as a modulator of osteogenesis. Ortop Traumatol Rehabil. 11(1): 1-6.
  3. Tezapsidis N, et al. (2009) Leptin: a novel therapeutic strategy for Alzheimer's disease. J Alzheimers Dis. 16(4): 731-40.
  4. Cai C, et al. (2009) Leptin in non-autoimmune inflammation. Inflamm Allergy Drug Targets. 8(4): 285-91.
  5. Fernández-Riejos P, et al. (2010) Role of leptin in the activation of immune cells. Mediators Inflamm. 2010: 568343.
  6. Kelesidis T, et al. (2010) Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Intern Med. 152(2): 93-100.

 

Leptin related areas, pathways, and other information

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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