Lefty2 Protein (Lefty A Protein)

Left-right determination factor 2 (Left-right determination, factor A)

Lefty2 Products

Lefty2 Protein, Recombinant

Molecule	Species	Description	Cat. No
Lefty2/Lefty A	Human	Lefty2/Lefty A/Fc Protein, Recombinant	10248-H01H

Lefty2 cDNA Clone

Molecule	Species	Description	Cat. No
Lefty2/Lefty A	Human	Homo sapiens Lefty2/Lefty A cDNA Clone(NM_003240.2)	HG10248-M
Lefty2/Lefty A	Rat	Rat Lefty2/Lefty A cDNA Clone	RG80129-G

Lefty2 Related Areas

Stem Cell>>Embryonic Stem Cell (ESC)>>Embryonic Stem Cell Marker>>Lefty2/Lefty A

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>Other>>Lefty2/Lefty A

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>Other>>Lefty2/Lefty A

Lefty2 Alternative Names

Lefty2, LEFTYA, LEFTA, EBAF, MGC46222, TGFB4 [Homo sapiens]

Lefty2, Lefta, Leftb, 6030463A22Rik, AV214969, Ebaf, MGC98569 [Mus musculus]

Lefty2 Background

left-right determination factor 2 (Lefty2), also known as Left-right determination factor A (Lefty A), endometrial bleeding associated factor (left-right determination, factor A transforming growth factor beta superfamily), and Transforming growth factor beta-4, is a member of the TGF-beta family of proteins. This protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. Lefty2/Lefty A may also play a role in endometrial bleeding. Mutations in Lefty2/Lefty A have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. Depletion of both Lefty1 and Lefty2 causes unchecked Nodal signaling, expansion of mesendoderm, and loss of ectoderm. The expansion of mesendoderm correlates with an extended period of rapid cellular internalization and a failure of deep-cell epiboly. The gastrulation defects of embryos depleted of Lefty1 and Lefty2 result from the deregulation of Squint signaling.

Lefty2 Related Studies

1. Feldman B, et al. (2002) Lefty antagonism of Squint is essential for normal gastrulation. Curr Biol. 12(24): 2129-35.
2. Meno C, et al. (1999) Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation. Mol Cell. 4(3): 287-98.
3. Meno C, et al. (2001) Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2. Dev Cell. 1(1): 127-38.