Lck Protein

Lymphocyte-specific protein tyrosine kinase

Lck Products

Lck Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
Lck	Human	Lck Protein, Recombinant, With GST Tag	10043-H09B

  10043-H09B:

1. The specific activity of Lck was determined to be 60 nmol / min / mg. The specific activity of Lck was determined by using a Poly (Glu:Tyr, 4:1) synthetic peptide substrate.

2. Measured by its ability to bind recombinant human CD3E in a functional ELISA.

Lck cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
Lck	Human	Homo sapiens Lck transcript variant 1 cDNA Clone	HG10043-M

Lck Related Areas

Enzyme>>Protein Kinase>>Intracellular Kinase>>Src (sarcoma) Family Kinase>>Lck

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>Src (sarcoma) Family Kinase>>Lck

Immunology>>Adaptive Immunity>>T Cell>>T Cell Antigen Recognition>>Lck

Lck Alternative Names

LCK, RP4-675E8.4, LSK, YT16, p56lck, pp58lck [Homo sapiens]

Lck, RP23-209C6.8, Hck-3, Lsk, Lskt, p56<lck>, p56Lck [Mus musculus]

Lck Background

Protein kinases are critically involved in signaling pathways that regulate cell growth, differentiation, activation, and survival. Initially identified as a T-cell specific member of the Src family of protein tyrosine kinases, Lck has become the object of intensive investigations which have revealed a key role for this kinase in the central processes controlling T-cell development, activation, proliferation and survival. Lck is expressed specifically in lymphoid cells. It contains one protein kinase domain, one SH2 domain, and one SH3 domain. It is associated with a variety of cell surface receptors and is critical for signal transduction from the T-cell antigen receptor (TCR). Consequently, Lck is targeted by regulatory proteins of T-lymphotropic viruses, especially by the Herpesvirus saimiri (HVS) tyrosine kinase interacting protein (Tip). This oncoprotein physically interacts with Lck in HVS transformed T cells and has an impact on its catalytic activity. Together with the identification of defects in the regulation of Lck expression or activity in T-cell leukemias, suggests that dysregulation of Lck might play a role in neoplastic transformation. However, under certain conditions Lck is also involved in the induction of apoptosis. This chemosensitizing effect of Lck is independent of T-cell receptor signaling and does not require the kinase activity of Lck. The findings demonstrate that Lck might be part of two independent signaling pathways leading to either cell proliferation or apoptosis.

Lck Related Studies

1. Majolini MB, et al. (1999) Dysregulation of the protein tyrosine kinase LCK in lymphoproliferative disorders and in other neoplasias. Leuk Lymphoma. 35(3-4): 245-54.
2. Isakov N, et al. (2000) Lck protein tyrosine kinase is a key regulator of T-cell activation and a target for signal intervention by Herpesvirus saimiri and other viral gene products. Eur J Biochem. 267(12): 3413-21.
3. Heyninck K, et al. (2006) A novel link between Lck, Bak expression and chemosensitivity. Oncogene. 25(12): 1693-5.