Layilin Protein & Antibody (LAYN)

Layilin

Layilin Products

Layilin Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Layilin	Human	Layilin/Fc Protein, Recombinant	10208-H02H
Layilin	Human	Layilin Protein, Recombinant	10208-H08H
Layilin	Cynomolgus	Layilin / LAYN Protein, Recombinant	90160-C02H
Layilin	Cynomolgus	Layilin / LAYN Protein, Recombinant	90160-C08H

Layilin Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human Layilin	WB	Mouse Monoclonal Antibody	10208-MM01
Human Layilin	ELISA	Mouse Monoclonal Antibody	10208-MM02
Human Layilin	WB, ELISA	Rabbit Polyclonal Antibody	10208-RP01
Human Layilin	WB, ELISA	Layilin Antibody (Antigen Affinity Purified)	10208-RP02
Human Layilin	ELISA	Layilin Antibody	10208-R007

Layilin ELISA Kit

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human Layilin	ELISA	Layilin ELISA Kit	SEK10208

Layilin cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Layilin	Human	Homo sapiens Layilin cDNA Clone (NM_178834.3)	HG10208-M
Layilin	Rat	Rat LAYN Gene cDNA Clone / ORF Clone	RG80431-G
Layilin	Cynomolgus	Cynomolgus monkey LAYN Gene cDNA Clone / ORF Clone	CG90160-G

Layilin Related Areas

Cancer>>Angiogenesis>>ECM Molecules in Angiogenesis>>Layilin

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Hyaluronic Acid Binding Protein>>Layilin

Immunology>>Adhesion Molecule>>Lectin>>Layilin

Layilin Alternative Names

Layilin, LAYN, FLJ30977, FLJ31092 [Homo sapiens]

Layilin, Layn, E030012M19Rik, Gm511 [Mus musculus]

Layilin Background

Layilin, a recently characterized as a 55 kDa transmembrane protein with homology to C-type lectins, is present in numerous cell lines and tissue extracts. As one of the adaptor proteins, talin mediates the interactions between the actin filaments and the cell membrane by binding to integral membrane proteins and to the cytoskeleton. Layilin is a newly identified membrane-binding site for talin in peripheral ruffles of spreading cells, a ten-amino acid motif in the layilin cytoplasmic domain is sufficient for talin binding, and its adjacent LH2-LH3 tandem arrays in the cytoplasmic domain provide docking sites for talin. Furthermore, talin binds layilin, PIPK1gamma and integrins in similar although subtly different ways. Layilin binds specifically to hyaluronan (HA) through its extracellular domain, a ubiquitous extracellular matrix component in most animal tissues and body fluids, but not to other tested glycosaminoglycans. The research suggests that layilin may mediate signals from extracellular matrix to the cell cytoskeleton via interaction with different intracellular binding partners and thereby be involved in the modulation of cortical structures in the cell. All the above actions reveal an interesting parallel between layilin and the known HA receptor CD44. In addition, merlin and radixin have been identified as different intracellular binding partners of layilin. Accordingly, it has been suggested that layilin plays roles in a variety of cellular processes, including cell shape, adhesion, motility, and homeostasis, as well as signal transduction. In addition, layilin might play an important role in the process of invasion and lymphatic metastasis of lung carcinoma.

Layilin Related Studies

1. Borowsky ML, et al. (1998) Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles.J Cell Biol. 143(2):429-42.
2. Bono P, et al. (2001) Layilin, a novel integral membrane protein, is a hyaluronan receptor. Mol Biol Cell. 12(4)891-900.
3. Bono P, et al. (2005) Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin. Exp Cell Res. 308(1):177-87.
4. Scoles DR. (2007) The merlin interacting proteins reveal multiple targets for NF2 therapy. Biochim Biophys Acta. 1785(1):32-54.
5. Chen Z, et al. (2008) Down-regulation of layilin, a novel hyaluronan receptor, via RNA interference, inhibits invasion and lymphatic metastasis of human lung A549 cells. Biotechnol Appl Biochem. 50(Pt 2):89-96.
6. Wegener KL, et al. (2008) Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain. J Mol Biol. 382(1):112-26.