- EGFR Signaling Pathway
- TGF-beta Signaling
- Canonical Wnt Signaling
- non-Canonical Wnt Signaling
- Notch Signaling
- p53 Pathway
- NF-kB Pathway
- Cytokine Signaling
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Layilin Antibody Datasheet
|Order or Inquire for Layilin Antibody product||Quality antibodies||Antibody production services|
|Detection limit is 0.00975 ng/well in ELISA|
Layilin Antibody Product Information
Recombinant Mouse Layilin protein (Catalog#10208-H08H)
|Antibody Type :||Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )|
Clone ID :
|Ig Type :||
|Formulation :||0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.|
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Layilin (rM Layilin; Catalog#10208-H08H; NP_849156.1; Met 1-Glu 220).
Layilin Antibody Usage Guide
|Direct ELISA :||This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human Layilin. The detection limit for Human Layilin is approximately 0.00975 ng/well.|
|Storage :||This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Layilin Antibody Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Layilin||Human||Layilin/Fc Protein, Recombinant||10208-H02H|
|Layilin||Human||Layilin Protein, Recombinant||10208-H08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|WB||Mouse Monoclonal Antibody||10208-MM01|
|ELISA||Mouse Monoclonal Antibody||10208-MM02|
|WB, ELISA||Rabbit Polyclonal Antibody||10208-RP01|
|WB, ELISA||Layilin Antibody (Antigen Affinity Purified)||10208-RP02|
Layilin Antibody Background
Layilin (LAYN), a recently characterized transmembrane protein with homology to C-type lectins, is present in numerous cell lines and tissue extracts. As one of the adaptor proteins, talin mediates the interactions between the actin filaments and the cell membrane by binding to integral membrane proteins and to the cytoskeleton. Layilin is a newly identified membrane-binding site for talin in peripheral ruffles of spreading cells, and its adjacent LH2-LH3 tandem arrays in the cytoplasmic domain provide docking sites for talin. Layilin binds specifically to hyaluronan (HA) through its extracellular domain, a ubiquitous extracellular matrix component in most animal tissues and body fluids, but not to other tested glycosaminoglycans. All the above actions reveal an interesting parallel between layilin and the known HA receptor CD44. In addition, merlin and radixin have been identified as different intracellular binding partners of layilin. Accordingly, it has been suggested that layilin plays roles in a variety of cellular processes, including cell shape, adhesion, motility, and homeostasis, as well as signal transduction.
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- Rees, D.J.G. et al., 1990, Nature. 347: 685-689.
- Bono, P. et al., 2005, Exp.Cell. Res. 308: 177-187.
- Schoenwaelder, S.M. et al., 1999, Curr Opin Cell Biol. 11: 274-286.