Latexin

Latexin is hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4

Latexin Related Areas

Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>Latexin/Lxn

Stem Cell>>Neural Stem Cell (NSC)>>Neuronal Cell Markers>>Latexin/Lxn

Immunology>>Innate Immunity>>Mast Cell>>Latexin/Lxn

Immunology>>Innate Immunity>>Monocyte/Macrophage>>Macrophage Marker>>Latexin/Lxn

Latexin Alternative Names

Latexin, LXN, ECI, TCI [Homo sapiens]

Latexin, lxn, MGC144352, MGC144353 [Mus musculus]

Summaries for Latexin

OMIM - description for Latexin:

Latexin is a specific inhibitor of zinc-dependent metallocarboxypeptidases (Pallares et al., 2005).

Human Latexin Protein General Information

 

• Protein names: Latexin
• Sequence length: 222 AA.
• Sequence similarities: Latexin belongs to the protease inhibitor I47 (latexin) family. [View classification]
• Subcellular location: Cytoplasm
• Tissue specificity: Latexin is highly expressed in heart, prostate, ovary, kidney, pancreas, and colon, moderate or low in other tissues including brain.

General information above from UniProt

Function for Latexin Protein

UniProtKB:

Latexin is hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4

Genatlas:

• Latexin is specific inhibitor of carboxypeptidase A
• metallocarboxypeptidases containing a characteristic alpha/beta hydrolase fold
• Latexin plays an important role in regulating the activity of hematopoietic stem cells (Kadouchi 2009)
• Latexin is the regulator of hematopoietic stem cells
• Latexin is involved in BMP2-induced chondrocyte differentiation and plays an important role in skeletogenesis and skeletal regeneration (Kadouchi 2009)

Homology for human Latexin

• homolog to rattus carboxypeptidase A inhibitor
• homolog to cystatins