Latexin / LXN Antibody

Latexin / LXN Antibody Datasheet

Latexin / LXN Antibody Product Information

• Immunogen: Recombinant Mouse Latexin / LXN protein (Catalog#50050-M07E)
• Antibody Type: Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
• Clone ID: 040
• Ig Type: Rabbit IgG
• Formulation: 0.2 μm filtered solution in PBS with 5% trehalose
• Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Latexin / LXN (rM Latexin / LXN; Catalog#50050-M07E; NP_058033.2; Glu 2-Glu 222).

Latexin / LXN Antibody Usage Guide

• Specificity: Mouse Latexin / LXN
• No cross-reactivity in ELISA with

  Human LXN

• Direct ELISA: This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse LXN. The detection limit for Mouse LXN is approximately 0.039 ng/well.
• Storage: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
  Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Latexin / LXN Antibody Background

Latexin, also known as tissue or endogenous carboxypeptidase inhibitor (TCI or ECI), is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional specification of the neocortex in development in rats. The 222 amino acid latexin in human shows different expression distribution with high levels in heart, prostate, ovary, kidney, pancreas, and colon, but only moderate or low levels in other tissues including brain. Latexin is also expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets, and thus is suggested to play a role in inflammation and innate immunity pathways. Despite of the non-detectable sequence similarity with plant and parasite inhibitors, Latexin is related to a human putative tumor suppressor protein, TIG1. In addition, Latexin is also implicated in Alzheimer's disease.

References

1. Liu, Q. et al., 2000, Mol. Biol. Rep. 27: 241-246.
2. Aagaard, A. et al., 2005, Structure 13: 309-317.
3. Pallares, I. et al., 2005, Proc. Natl. Acad. Sci. USA. 102: 3978-3983.