**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-LXN rabbit polyclonal antibody at 1:500 dilution
Lane A: Hela Whole Cell Lysate
Lane B: HL60 Whole Cell LysateLysates/proteins at 30 μg per lane.
Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.Developed using the Odyssey technique.
Performed under reducing conditions.Predicted band size:26 kDa
Observed band size:30 kDa
(We are unsure as to the identity of these extra bands.)
Latexin, also known as endogenous carboxypeptidase inhibitor, tissue carboxypeptidase inhibitor, TCI, ECI and LXN, is a cytoplasm protein which belongs to the protease inhibitor I47 (latexin) family. It is highly expressed in heart, prostate, ovary, kidney, pancreas, and colon. Latexin / LXN is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional specification of the neocortex in development in rats. The 222 amino acid latexin in human shows different expression distribution with high levels in heart, prostate, ovary, kidney, pancreas, and colon, but only moderate or low levels in other tissues including brain. Latexin is also expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets, and thus is suggested to play a role in inflammation and innate immunity pathways. Despite of the non-detectable sequence similarity with plant and parasite inhibitors, Latexin is related to a human putative tumor suppressor protein, TIG1. In addition, Latexin is also implicated in Alzheimer's disease.
|Product Description||Host||Clonality||Application||Catalog# (PDF)|
|Anti-Latexin Antibody (FITC)||Rabbit||Monoclonal||FCM||10211-R101-F|
|Anti-Latexin Antibody (FITC)||Mouse||Monoclonal||FCM||10211-MM02-F|
|Anti-Latexin Antibody (PE)||Rabbit||Monoclonal||FCM||10211-R101-P|
|Anti-Latexin Antibody (PE)||Mouse||Monoclonal||FCM||10211-MM02-P|