Anti-Latexin Antibody

Cat: 10211-RP01
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Anti-Latexin Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Latexin Antibody
Validated applications
WB,ELISA
Species reactivity
Reacts with: Human
Specificity
Human Latexin
Immunogen
Recombinant Human Latexin protein (Catalog#10211-H07E)
Preparation
Produced in rabbits immunized with purified, recombinant Human Latexin (rh Latexin; Catalog#10211-H07E; NP_064554.3; Glu 2-Glu 222). Total IgG was purified by Protein A affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Latexin Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:1000  
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Latexin Antibody (Rabbit Polyclonal antibody) Images
Human Latexin Western blot (WB) 13146

Anti-LXN rabbit polyclonal antibody at 1:500 dilution

Lane A: Hela Whole Cell Lysate

Lane B: HL60 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:26 kDa

Observed band size:30 kDa

(We are unsure as to the identity of these extra bands.)

Anti-Latexin Antibody Alternative Names
Anti-ECI Antibody;Anti-TCI Antibody
Latexin Background Information

Latexin, also known as endogenous carboxypeptidase inhibitor, tissue carboxypeptidase inhibitor, TCI, ECI and LXN, is a cytoplasm protein which belongs to the protease inhibitor I47 (latexin) family. It is highly expressed in heart, prostate, ovary, kidney, pancreas, and colon. Latexin / LXN is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional specification of the neocortex in development in rats. The 222 amino acid latexin in human shows different expression distribution with high levels in heart, prostate, ovary, kidney, pancreas, and colon, but only moderate or low levels in other tissues including brain. Latexin is also expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets, and thus is suggested to play a role in inflammation and innate immunity pathways. Despite of the non-detectable sequence similarity with plant and parasite inhibitors, Latexin is related to a human putative tumor suppressor protein, TIG1. In addition, Latexin is also implicated in Alzheimer's disease.

Full Name
latexin
References
  • Liu Q., et al.,(2000), Cloning, tissue expression pattern and genomic organization of latexin, a human homologue of rat carboxypeptidase A inhibitor. Mol. Biol. Rep. 27:241-246.
  • Gauci S., et al., (2009), Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.nal. Chem. 81:4493-4501.
  • Muzny D.M., et al.,(2006), The DNA sequence, annotation and analysis of human chromosome 3.Nature 440:1194-1198.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Latexin Antibody Rabbit Monoclonal ELISA 50050-R009
    Anti-Latexin Antibody Rabbit Monoclonal ELISA 50050-R040
    Anti-Latexin Antibody Rabbit Polyclonal WB,ELISA,IP 50050-RP02
    Anti-Latexin Antibody Rabbit Polyclonal ELISA 50050-RP01
    Anti-Latexin Antibody (FITC) Rabbit Monoclonal FCM 10211-R101-F
    Anti-Latexin Antibody Rabbit Polyclonal WB,ELISA,IP 10211-RP02
    Anti-Latexin Antibody Mouse Monoclonal FCM,ICC/IF,IF 10211-MM02
    Anti-Latexin Antibody (FITC) Mouse Monoclonal FCM 10211-MM02-F
    Anti-Latexin Antibody (PE) Rabbit Monoclonal FCM 10211-R101-P
    Anti-Latexin Antibody (PE) Mouse Monoclonal FCM 10211-MM02-P
    Anti-Latexin Antibody Mouse Monoclonal WB,ELISA,IP 10211-MM04
    Anti-Latexin Antibody Rabbit Monoclonal WB,ELISA,FCM,ICC/IF,IF,IP 10211-R101
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