LYPLA2 Protein

Lysophospholipase 2 / Lysophospholipase II

LYPLA2 Products

LYPLA2 Protein, Recombinant

Molecule	Species	Description	Cat. No
LYPLA2	Human	LYPLA2 Protein, Recombinant	12360-H07E

LYPLA2 Related Areas

Cardiovascular>>Lipid Metabolism>>LYPLA2

LYPLA2 Alternative Names

LYPLA2, RP5-886K2.5, APT-2, DJ886K2.4 [Homo sapiens]

Lypla2, RP23-161N17.9, LysoII [Mus musculus]

LYPLA2 Background

Lysophospholipase II (LYPLA2, LPL-II, or LysoPLA II), also known as Acyl-protein thioesterase 2 (APT-2), belongs to the AB hydrolase 2 family. This enzyme has lysophospholipase activity, and may hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Acyl-protein thioesterase 1 (APT-1) and Acyl-protein thioesterase 2 (APT-2) are cytosolic lysophospholipid hydrolyzing enzymes. The serum activity of APT-1 may play an important role in determination of the concentration of des-acyl ghrelin in circulation, especially under septic inflammation. APT-2/LYPLA2 is expressed both in CHO-K1 and HeLa cells and its overexpression increased the deacylation rate of single acylated GAP-43 and affected the steady-state localization of diacylated GAP-43 and H-Ras. Thus, the results demonstrate that APT-2/LYPLA2 is the protein thioesterase involved in the acylation/deacylation cycle operating in GAP-43 subcellular distribution.

LYPLA2 Related Studies

1. Satou M, et al. (2010) Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium. Endocrinology. 151(10): 4765-75.
2. Tomatis VM, et al. (2010) Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43. PLoS One. 5(11): e15045.