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LTBR/TNFRSF3 Protein, Antibody, ELISA Kit, cDNA Clone

LTBR/TNFRSF3 Related Areas

LTBR/TNFRSF3 Related Pathways

LTBR/TNFRSF3 Related Product

LTBR/TNFRSF3 Summary & Protein Information

LTBR/TNFRSF3 Related Information

LTBR/TNFRSF3 Background

Gene Summary: The protein encoded by this LTBR gene is a member of the tumor necrosis factor (TNF) family of receptors. The LTBR protein is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The LTBR protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). LTBR, the encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis.
General information above from NCBI
Subunit structure: Self-associates. Associates with TRAF3, TRAF4 and TRAF5. Interacts with HCV core protein.
Subcellular location: Membrane; Single-pass type I membrane protein.
Sequence similarity: Contains 4 TNFR-Cys repeats.C
General information above from UniProt

LTBR (lymphotoxin beta receptor (TNFR superfamily, member 3)) is a member of the tumor necrosis factor (TNF) family of receptors. Tumor necrosis factor receptor is a trimeric cytokine receptor that binds tumor necrosis factors. The receptor cooperates with an adaptor protein (such as TRADD, TRAF, RIP), which is important in determining the outcome of the response. LTBR is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. LTBR specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). LTBR and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of this protein can trigger apoptosis. Not only does the LTBR help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of LTBR in HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. It is also essential for development and organization of the secondary lymphoid organs and chemokine release.

LTBR/TNFRSF3 Alternative Name

CD18,D12S370,LT-BETA-R,lymphotoxin B receptor,lymphotoxin-beta receptor,member 3,TNFCR,TNFR superfamily,TNFR2-RP,TNF-RIII,TNFR-III,TNF-R-III,TNFR-RP,TNFRSF3,tumor necrosis factor C receptor,tumor necrosis factor receptor 2-related protein,tumor necrosis factor receptor superfamily,tumor necrosis factor receptor superfamily member 3,tumor necrosis factor receptor type III, [human]
AI256028,CD18,LT beta-R,Ltar,LT-beta receptor,LTbetaR,lymphotoxin-beta receptor,member 3,TNF receptor-related protein,Tnfbr,TNFCR,TNFR2-RP,TNF-R-III,TNFRrp,TNFR-RP,Tnfrsf3,tumor necrosis factor receptor superfamily,tumor necrosis factor receptor superfamily member 3, [mouse]

LTBR/TNFRSF3 Related Studies

  • Summers deLuca L, et al. (2011) A LTβR signaling in dendritic cells induces a type I IFN response that is required for optimal clonal expansion of CD8+ T cells. Proc Natl Acad Sci. 108(5):2046-51.
  • Bista P, et al. (2010) TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor. J Biol Chem. 285(17):12971-8.
  • Xu Y, et al. (2011) Adiponectin inhibits lymphotoxin-β receptor-mediated NF-κB signaling in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 404(4):1060-4.
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