All LTBR reagents are produced in house and quality controlled, including 2 LTBR Antibody, 51 LTBR Gene, 4 LTBR Lysate, 4 LTBR Protein, 2 LTBR qPCR. All LTBR reagents are ready to use.
Recombinant LTBR proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-His.
LTBRantibodies are validated with different applications, which are ELISA.
LTBRcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each LTBR of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
LTBR (lymphotoxin beta receptor (TNFR superfamily, member 3)) is a member of the tumor necrosis factor (TNF) family of receptors. Tumor necrosis factor receptor is a trimeric cytokine receptor that binds tumor necrosis factors. The receptor cooperates with an adaptor protein (such as TRADD, TRAF, RIP), which is important in determining the outcome of the response. LTBR is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. LTBR specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). LTBR and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of this protein can trigger apoptosis. Not only does the LTBR help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of LTBR in HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. It is also essential for development and organization of the secondary lymphoid organs and chemokine release.