LSAMP

Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection

LSAMP Related Areas

 

LSAMP Alternative Names

LSAMP, FLJ34254, FLJ35396, FLJ37216, FLJ54658, IGLON3, LAMP [Homo sapiens]

Lsamp, 5430428I19, AW046674, B130007O04Rik, D930023J12Rik, Lam, Lamp [Mus musculus]

Summaries for LSAMP

Entrez Gene summary for LSAMP:

The protein encoded by this gene is a neuronal surface glycoprotein found in cortical and subcortical regions of the limbic system. During development of the limbic system, this encoded protein is found on the surface of axonal membranes and growth cones, where it acts as a selective homophilic adhesion molecule, and guides the development of specific patterns of neuronal connections.

OMIM - description for LSAMP:

LAMP (or LSAMP) is a 64- to 68-kD neuronal surface glycoprotein found in cortical and subcortical regions of the limbic system. During development of the limbic system, LAMP is found on the surface of axonal membranes and growth cones, where it acts as a selective homophilic adhesion molecule, and guides the development of specific patterns of neuronal connections

Wikipedia summary for LSAMP:

Human LSAMP Protein General Information

 

• Protein names: Recommended name: Limbic system-associated membrane protein Short name=LSAMP
• Sequence length: 338 AA.
• Domain: Immunoglobulin domain Repeat Signal
• Sequence similarities: Belongs to the immunoglobulin superfamily. IgLON family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
• Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor.
• Tissue specificity: Expressed on limbic neurons and fiber tracts as well as in single layers of the superior colliculus, spinal chord and cerebellum.

General information above from UniProt

Function for LSAMP Protein

UniProtKB:

Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection

Genatlas:

• LSAMP mediates selective neuronal growth and axon targeting
• neuronal surface glycoprotein found in the cortical and subcortical regions of the limbic system
• LSAMP function as a tumor suppressor gene in clear cell renal cell carcinoma
• neuronal adhesive molecule, preferentially expressed in developing limbic system neuronal dendrites and somata (Must 2008)
• LSAMP might play a role in pathoaetiology of suicidal behaviour (Must 2008)
• LSAMP candidate tumor suppressor gene in osteosarcomas (Kresse 2009)