All LSAMP reagents are produced in house and quality controlled, including 12 LSAMP Gene, 2 LSAMP Lysate, 2 LSAMP Protein, 1 LSAMP qPCR. All LSAMP reagents are ready to use.
Recombinant LSAMP proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-His.
LSAMPcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each LSAMP of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
The limbic system-associated membrane protein (LAMP) is a cell surface glycoprotein expressed by cortical and subcortical regions of the mammalian CNS that comprise or receive direct projections from limbic system structures. The 64-68-kDa glycoprotein limbic system-associated membrane protein (LsAMP) is expressed on the surface of somata and proximal dendrites of neurons. These areas perform cognitive and autonomic functions, also learning and memory. The functional analysis indicates that LsAMP acts as a selective adhesion molecule, serving as a guidance cue for specific patterns of connectivity, which underlies the normal development of the limbic system. In animal studies there have been found that rats with increased level of anxiety had 1.6-fold higher expression of LsAMP gene in the periaqueductal gray compared to rats with low level of anxiety, indicating a possible role of LsAMP in the regulation of anxiety.