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LSAMP Protein, Antibody, ELISA Kit, cDNA Clone

LSAMP Related Areas

LSAMP Related Pathways

LSAMP Related Product

    LSAMP Summary & Protein Information

    LSAMP Background

    Gene Summary: The protein encoded by this gene is a neuronal surface glycoprotein found in cortical and subcortical regions of the limbic system. During development of the limbic system, this encoded protein is found on the surface of axonal membranes and growth cones, where it acts as a selective homophilic adhesion molecule, and guides the development of specific patterns of neuronal connections.
    General information above from NCBI
    Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
    Tissue specificity: Expressed on limbic neurons and fiber tracts as well as in single layers of the superior colliculus, spinal chord and cerebellum.
    Sequence similarity: Belongs to the immunoglobulin superfamily. IgLON family.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.C
    General information above from UniProt

    The limbic system-associated membrane protein (LAMP) is a cell surface glycoprotein expressed by cortical and subcortical regions of the mammalian CNS that comprise or receive direct projections from limbic system structures. The 64-68-kDa glycoprotein limbic system-associated membrane protein (LsAMP) is expressed on the surface of somata and proximal dendrites of neurons. These areas perform cognitive and autonomic functions, also learning and memory. The functional analysis indicates that LsAMP acts as a selective adhesion molecule, serving as a guidance cue for specific patterns of connectivity, which underlies the normal development of the limbic system. In animal studies there have been found that rats with increased level of anxiety had 1.6-fold higher expression of LsAMP gene in the periaqueductal gray compared to rats with low level of anxiety, indicating a possible role of LsAMP in the regulation of anxiety.

    LSAMP Alternative Name

    FLJ34254,FLJ54658,LSAMP,FLJ35396,FLJ37216,IGLON3,LAMP, [human]
    5430428I19,AW046674,B130007O04Rik,D930023J12Rik,Lam,Lamp,Lsamp, [mouse]

    LSAMP Related Studies

  • Zacco A. et al., 1990, The Journal of Neuroscience. 10(1): 73-90.
  • Pimenta AF. et al., 1996, Gene. 170(2) :189-95.
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