LRPAP1 (Protein|Antibody|cDNA Clone|ELISA Kit)

All LRPAP1 reagents are produced in house and quality controlled, including 13 LRPAP1 Antibody, 30 LRPAP1 Gene, 5 LRPAP1 IPKit, 2 LRPAP1 Lysate, 2 LRPAP1 Protein, 2 LRPAP1 qPCR. All LRPAP1 reagents are ready to use.

Recombinant LRPAP1 proteins are expressed by HEK293 Cells with fusion tags as C-His.

LRPAP1antibodies are validated with different applications, which are ELISA, WB, IHC-P, ICC/IF, IF, IP.

LRPAP1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each LRPAP1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

LRPAP1 Protein (2)

Species

LRPAP1 Protein, Mouse, Recombinant (His Tag)

50281-M08H

Expression host: HEK293 Cells

Mouse LRPAP1/A2MRAP Protein 11541

LRPAP1 Protein, Human, Recombinant (His Tag)

11100-H08H

Expression host: HEK293 Cells

Human LRPAP1/A2MRAP Protein 9414
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LRPAP1 Antibody (13)

Application Clonality
Host

Anti-LRPAP1 Antibody

11100-MM01

Application: WB,ELISA,IHC-P,IP

Clonality: MAb

Human LRPAP1/A2MRAP Immunohistochemistry(IHC) 3933

Anti-LRPAP1 Antibody

50281-R009

Application: WB,ELISA,IHC-P,IP

Clonality: MAb

Mouse LRPAP1/A2MRAP Immunohistochemistry(IHC) 3244

Anti-LRPAP1 Antibody

107474-T10

Application: IHC-P,ICC/IF,IF

Clonality: PAb

Human LRPAP1 Immunohistochemistry(IHC) 19561

Anti-LRPAP1 Antibody

11100-M105

Application: ELISA

Clonality: MAb

Anti-LRPAP1 Antibody

11100-RP02

Application: WB,ELISA,IHC-P,IP

Clonality: PAb

Human LRPAP1/A2MRAP Immunohistochemistry(IHC) 3927

Anti-LRPAP1 Antibody

11100-M003

Application: IHC-P

Clonality: MAb

Human LRPAP1/A2MRAP Immunohistochemistry(IHC) 3929

Anti-LRPAP1 Antibody

11100-M034

Application: WB

Clonality: MAb

Human LRPAP1/A2MRAP Western blot (WB) 13341

Anti-LRPAP1 Antibody

11100-R004

Application: WB,ELISA,ICC/IF,IF,IP

Clonality: MAb

Human LRPAP1/A2MRAP Immunofluorescence(IF) 2894

Anti-LRPAP1 Antibody

11100-RP01

Application: ELISA

Clonality: PAb

Anti-LRPAP1 Antibody

50281-RP02

Application: WB,ELISA,IHC-P,IP

Clonality: PAb

Mouse LRPAP1/A2MRAP Immunohistochemistry(IHC) 3241

Anti-LRPAP1 Antibody

11100-MM34

Application: WB

Clonality: MAb

Human LRPAP1/A2MRAP Western blot (WB) 13341

Anti-LRPAP1 Antibody

50281-R011

Application: IHC-P

Clonality: MAb

Mouse LRPAP1/A2MRAP Immunohistochemistry(IHC) 3242

Anti-LRPAP1 Antibody

50281-RP01

Application: ELISA

Clonality: PAb

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LRPAP1 cDNA Clone (30)

Mouse
Human
Rat

LRPAP1 qPCR Primer (2)

LRPAP1 IP Kit (5)

LRPAP1 Lysate (2)

Receptor-associated protein (RAP) is a molecular chaperone for low density lipoprotein receptor-related protein (LRP), which plays a key role in cholesterol metabolism. The lipoprotein receptor-related protein (LRP) is an endocytic receptor for several ligands, such as alpha2-macroglobulin (alpha2 M) and apolipoprotein E. LRP is involved in the clearance of lipids from the bloodstream and is expressed in the atherosclerotic plaque. The LRP-associated protein (LRPAP in humans, RAP in mice) acts as a chaperone protein, stabilizing the nascent LRP peptide in the endoplasmic reticulum and Golgi complex. Alpha-2-macroglobulin receptor-associated protein, also known as low density lipoprotein receptor-related protein-associated protein 1, RAP and LRPAP1, is a 39 kDa protein and a member of the alpha-2-MRAP family. It is a receptor antagonist that interacts with several members of the low density lipoprotein (LDL) receptor gene family. Upon binding to these receptors, LRPAP1 inhibits all ligand interactions with the receptors. LRPAP1 is present on cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains. It binds with LRP1B and the binding is followed by internalization and degradation. LRPAP1 interacts with LRP1/alpha-2-macroglobulin receptor and LRP2 (previously called glycoprotein 330), and may be involved in the pathogenesis of membrane glomerular nephritis. LRPAP1 together with LRP2 forms the Heymann nephritis antigenic complex. LRP2 is expressed in epithelial cells of the thyroid, where it can serve as a receptor for the protein thyroglobulin. Intron 5 insertion/deletion polymorphism of RAP gene (LRPAP1) has been implicated in other diseases sharing etiology with gallstone disease (GSD). The LRPAP1 insertion/deletion polymorphism influences cholesterol homeostasis and may confer risk for gallstone disease and gallbladder carcinoma (GBC) incidence usually parallels with the prevalence of cholelithiosis. The genetic variations at the LRPAP1 locus may modulate Alzheimer disease (AD) phenotype beyond risk for disease. In addition, the variation at the LRPAP1 gene could contribute to the risk of developing an early episode of myocardial infarction (MI).

Protein
Antibody
Gene
qPCR
IPKit
Lysate
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