LRPAP1 Protein & Antibody (RAP)

Low density lipoprotein receptor-related protein associated protein 1

LRPAP1 Products

LRPAP1 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
LRPAP1	Human	LRPAP1 Protein, Recombinant	11100-H08H
LRPAP1	Mouse	LRPAP1 Protein, Recombinant	50281-M08H

  11100-H08H: Immobilized human LRPAP1 at 0.5µg/mL can bind human VLDLR with a range of 3.2-400 ng/ml. Measured by its binding ability in a functional ELISA.

  50281-M08H: Immobilized mouse LRPAP1 at 0.5 μg/mL can bind human VLDLR with a linear range of  1.28 - 32 ng/ml. Measured by its binding ability in a functional ELISA.

LRPAP1 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human LRPAP1	WB, ELISA	Mouse Monoclonal Antibody	11100-MM01
Human LRPAP1	WB	LRPAP1 Antibody	11100-MM34
Human LRPAP1	WB, ELISA	Rabbit Monoclonal Antibody	11100-R004
Mouse LRPAP1	WB, ELISA	LRPAP1 Antibody	50281-R009
Human LRPAP1	WB, ELISA	Rabbit Polyclonal Antibody	11100-RP01
Human LRPAP1	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11100-RP02
Mouse LRPAP1	WB, ELISA	LRPAP1 Antibody	50281-RP01
Mouse LRPAP1	WB, ELISA	LRPAP1 Antibody (Antigen Affinity Purified)	50281-RP02

LRPAP1 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
LRPAP1	Human	Homo sapiens LRPAP1 cDNA Clone	HG11100-M
LRPAP1	Mouse	Mus musculus LRPAP1 cDNA Clone	MG50281-M

LRPAP1 Related Areas

Cardiovascular>>Lipid Metabolism>>LRPAP1

LRPAP1 Alternative Names

LRPAP1, RAP, HBP44, RP11-529E10.3, A2MRAP, A2RAP, MGC138272, MRAP [Homo sapiens]

LRPAP1, RAP, HBP44, AA617339, AI790446, AU042172, C77774 [Mus musculus]

LRPAP1 Background

Receptor-associated protein (RAP) is a molecular chaperone for low density lipoprotein receptor-related protein (LRP), which plays a key role in cholesterol metabolism. The lipoprotein receptor-related protein (LRP) is an endocytic receptor for several ligands, such as alpha2-macroglobulin (alpha2 M) and apolipoprotein E. LRP is involved in the clearance of lipids from the bloodstream and is expressed in the atherosclerotic plaque. The LRP-associated protein (LRPAP in humans, RAP in mice) acts as a chaperone protein, stabilizing the nascent LRP peptide in the endoplasmic reticulum and Golgi complex. Alpha-2-macroglobulin receptor-associated protein, also known as low density lipoprotein receptor-related protein-associated protein 1, RAP and LRPAP1, is a 39 kDa protein and a member of the alpha-2-MRAP family. It is a receptor antagonist that interacts with several members of the low density lipoprotein (LDL) receptor gene family. Upon binding to these receptors, LRPAP1 inhibits all ligand interactions with the receptors. LRPAP1 is present on cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains. It binds with LRP1B and the binding is followed by internalization and degradation. LRPAP1 interacts with LRP1/alpha-2-macroglobulin receptor and LRP2 (previously called glycoprotein 330), and may be involved in the pathogenesis of membrane glomerular nephritis. LRPAP1 together with LRP2 forms the Heymann nephritis antigenic complex. LRP2 is expressed in epithelial cells of the thyroid, where it can serve as a receptor for the protein thyroglobulin. Intron 5 insertion/deletion polymorphism of RAP gene (LRPAP1) has been implicated in other diseases sharing etiology with gallstone disease (GSD). The LRPAP1 insertion/deletion polymorphism influences cholesterol homeostasis and may confer risk for gallstone disease and gallbladder carcinoma (GBC) incidence usually parallels with the prevalence of cholelithiosis. The genetic variations at the LRPAP1 locus may modulate Alzheimer disease (AD) phenotype beyond risk for disease. In addition, the variation at the LRPAP1 gene could contribute to the risk of developing an early episode of myocardial infarction (MI).

LRPAP1 Related Studies

1. González P, et al. (2002) Variation in the lipoprotein receptor-related protein, alpha2-macroglobulin and lipoprotein receptor-associated protein genes in relation to plasma lipid levels and risk of early myocardial infarction. Coron Artery Dis. 13(5): 251-4.
2. Schutte DL, et al. (2003) A LRPAP1 intronic insertion/deletion polymorphism and phenotypic variability in Alzheimer disease. Res Theory Nurs Pract. 17(4): 301-19．
3. Pandey SN, et al. (2006) Lipoprotein receptor associated protein (LRPAP1) insertion/deletion polymorphism: association with gallbladder cancer susceptibility. Int J Gastrointest Cancer. 37(4): 124-8.
4. Dixit M, et al. (2006) Association of low density lipoprotein receptor related protein-associated protein (LRPAP1) gene insertion/deletion polymorphism with gallstone disease.J Gastroenterol Hepatol. 21(5): 847-9.