Anti-LRPAP1 Antibody

Cat: 11100-MM34
Contact us:
All LRPAP1 Reagents
CRO Services
Product recommended

All LRPAP1 Reagents
Anti-LRPAP1 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-LRPAP1 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human LRPAP1
Recombinant Human LRPAP1 protein (Catalog#11100-H08H)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human LRPAP1 (rh LRPAP1; Catalog#11100-H08H; NP_002328.1; Tyr 35-Leu 357). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Monoclonal Mouse IgG1 Clone #34
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-LRPAP1 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-LRPAP1 Antibody (Mouse Monoclonal antibody) Images
Human LRPAP1/A2MRAP Western blot (WB) 13341

Anti-LRPAP1 mouse monoclonal antibody at 1:500 dilution

Lane A: 293T Whole Cell Lysate

Lane B: A549 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.


Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:41 kDa

Observed band size:42 kDa

Anti-LRPAP1 Antibody Alternative Names
Anti-A2MRAP Antibody;Anti-A2RAP Antibody;Anti-alpha-2-MRAP Antibody;Anti-HBP44 Antibody;Anti-MRAP Antibody;Anti-MYP23 Antibody;Anti-RAP Antibody
LRPAP1 Background Information

Receptor-associated protein (RAP) is a molecular chaperone for low density lipoprotein receptor-related protein (LRP), which plays a key role in cholesterol metabolism. The lipoprotein receptor-related protein (LRP) is an endocytic receptor for several ligands, such as alpha2-macroglobulin (alpha2 M) and apolipoprotein E. LRP is involved in the clearance of lipids from the bloodstream and is expressed in the atherosclerotic plaque. The LRP-associated protein (LRPAP in humans, RAP in mice) acts as a chaperone protein, stabilizing the nascent LRP peptide in the endoplasmic reticulum and Golgi complex. Alpha-2-macroglobulin receptor-associated protein, also known as low density lipoprotein receptor-related protein-associated protein 1, RAP and LRPAP1, is a 39 kDa protein and a member of the alpha-2-MRAP family. It is a receptor antagonist that interacts with several members of the low density lipoprotein (LDL) receptor gene family. Upon binding to these receptors, LRPAP1 inhibits all ligand interactions with the receptors. LRPAP1 is present on cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains. It binds with LRP1B and the binding is followed by internalization and degradation. LRPAP1 interacts with LRP1/alpha-2-macroglobulin receptor and LRP2 (previously called glycoprotein 330), and may be involved in the pathogenesis of membrane glomerular nephritis. LRPAP1 together with LRP2 forms the Heymann nephritis antigenic complex. LRP2 is expressed in epithelial cells of the thyroid, where it can serve as a receptor for the protein thyroglobulin. Intron 5 insertion/deletion polymorphism of RAP gene (LRPAP1) has been implicated in other diseases sharing etiology with gallstone disease (GSD). The LRPAP1 insertion/deletion polymorphism influences cholesterol homeostasis and may confer risk for gallstone disease and gallbladder carcinoma (GBC) incidence usually parallels with the prevalence of cholelithiosis. The genetic variations at the LRPAP1 locus may modulate Alzheimer disease (AD) phenotype beyond risk for disease. In addition, the variation at the LRPAP1 gene could contribute to the risk of developing an early episode of myocardial infarction (MI).

Full Name
low density lipoprotein receptor-related protein associated protein 1
  • Gonzlez P, et al. (2002) Variation in the lipoprotein receptor-related protein, alpha2-macroglobulin and lipoprotein receptor-associated protein genes in relation to plasma lipid levels and risk of early myocardial infarction. Coron Artery Dis. 13(5): 251-4.
  • Schutte DL, et al. (2003) A LRPAP1 intronic insertion/deletion polymorphism and phenotypic variability in Alzheimer disease. Res Theory Nurs Pract. 17(4): 301-19?
  • Pandey SN, et al. (2006) Lipoprotein receptor associated protein (LRPAP1) insertion/deletion polymorphism: association with gallbladder cancer susceptibility. Int J Gastrointest Cancer. 37(4): 124-8.
  • Dixit M, et al. (2006) Association of low density lipoprotein receptor related protein-associated protein (LRPAP1) gene insertion/deletion polymorphism with gallstone disease.J Gastroenterol Hepatol. 21(5): 847-9.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-LRPAP1 Antibody Rabbit Monoclonal IHC-P 50281-R011
    Anti-LRPAP1 Antibody Rabbit Polyclonal ELISA 50281-RP01
    Anti-LRPAP1 Antibody Rabbit Monoclonal WB,ELISA,IHC-P,IP 50281-R009
    Anti-LRPAP1 Antibody Rabbit Polyclonal WB,ELISA,IHC-P,IP 50281-RP02
    Anti-LRPAP1 Antibody Rabbit Polyclonal WB,ELISA,IHC-P,IP 11100-RP02
    Anti-LRPAP1 Antibody Mouse Monoclonal ELISA 11100-M105
    Anti-LRPAP1 Antibody Mouse Monoclonal WB,ELISA,IHC-P,IP 11100-MM01
    Anti-LRPAP1 Antibody Rabbit Monoclonal WB,ELISA,ICC/IF,IF,IP 11100-R004
    Anti-LRPAP1 Antibody Rabbit Polyclonal ELISA 11100-RP01
    Anti-LRPAP1 Antibody Mouse Monoclonal IHC-P 11100-M003
    info info
    添加购物车成功! 添加购物车失败!