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LRPAP1 Antibody, Mouse MAb
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LRPAP1 Antibody, Mouse MAb PDF Download

Catalog   Size (Price) Quantity In Stock Operation
11100-MM34  

YES   
 

Primary antibody | Secondary antibody | Tag antibody | Isotype control antibody | Loading control antibody | Antibody Purification

LRPAP1 Antibody Datasheet

  Order or Inquire for LRPAP1 Antibody product Quality antibodies Antibody production services
 

LRPAP1 Antibody Product Information

Immunogen :

Recombinant Human LRPAP1 protein (Catalog#11100-H08H)

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )

Clone ID :

34

Ig Type :

Mouse IgG1

Formulation : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
Preparation :

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human LRPAP1 (rh LRPAP1; Catalog#11100-H08H; NP_002328.1; Tyr 35-Leu 357). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

LRPAP1 Antibody Usage Guide

Specificity :

Human LRPAP1

Western blot :

This antibody can be used at 2-5 μg/mL with the appropriate secondary reagents to detect Human LRPAP1 in WB.

LRPAP1 Western blot
  A B
Sample
(whole cell lysate)
293T A549
Sample Volume
(cells/lane)
5×105 5×105
Gel 13% SDS-PAGE reducing gel
Recommended Concentration 2-5 μg/ml
Secondary Antibody Dylight 800-labeled Antibody To Mouse IgG (H+L), at 1:20000 dilution.
Storage : This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

LRPAP1 Antibody Related Products & Topics

Related Areas:

Cardiovascular>>Lipid Metabolism>>LRPAP1

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
LRPAP1 Human LRPAP1 Protein, Recombinant 11100-H08H
LRPAP1 Mouse LRPAP1 Protein, Recombinant 50281-M08H

Antibodies:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
LRPAP1
WB, ELISA Mouse Monoclonal Antibody 11100-MM01
Human
LRPAP1
WB LRPAP1 Antibody 11100-MM34
Human
LRPAP1
WB, ELISA Rabbit Monoclonal Antibody 11100-R004
Mouse
LRPAP1
WB, ELISA LRPAP1 Antibody 50281-R009
Human
LRPAP1
WB, ELISA Rabbit Polyclonal Antibody 11100-RP01
Human
LRPAP1
WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified) 11100-RP02
Mouse
LRPAP1
WB, ELISA LRPAP1 Antibody 50281-RP01
Mouse
LRPAP1
WB, ELISA LRPAP1 Antibody (Antigen Affinity Purified) 50281-RP02

LRPAP1 Antibody Background

Alpha-2-macroglobulin receptor-associated protein, also known as low density lipoprotein receptor-related protein-associated protein 1, RAP and LRPAP1, is a 39 kDa protein and a member of the alpha-2-MRAP family. LRPAP1 is a receptor antagonist that interacts with several members of the low density lipoprotein (LDL) receptor gene family. Upon binding to these receptors, LRPAP1 inhibits all ligand interactions with the receptors. LRPAP1 is present on cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains. It binds with LRP1B and the binding is followed by internalization and degradation. LRPAP1 interacts with LRP1/alpha-2-macroglobulin receptor and LRP2 (previously called glycoprotein 330), and may be involved in the pathogenesis of membrane glomerular nephritis. LRPAP1 together with LRP2 forms the Heymann nephritis antigenic complex. LRP2 is expressed in epithelial cells of thethyroid, where it can serve as a receptor for the proteinthyroglobulin.

References

  1. Liu, CX. et al., 2001, J. Biol. Chem. 276: 28889-96.
  2. Schutte DL, et al., 2003,Res Theory Nurs Pract.17 (4): 301-19.
  3. Jensen, GA. et al., 2006, J. Mol. Biol. 362: 700-16.
  4. Santovito, A. et al., 2007, Hum Biol. 79 (6): 699-706.
 
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"