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LRIG1 Protein, Antibody, ELISA Kit, cDNA Clone

LRIG1 Related Areas

LRIG1 Related Pathways

LRIG1 Related Product

LRIG1 Summary & Protein Information

LRIG1 Background

Gene Summary: OMIM - description for LRIG1 :
General information above from NCBI
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
A phosphoprotein + H(2)O = a protein + phosphate.
Subunit structure: Interacts with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4.
Domain: The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when these two domains are deleted.
Subcellular location: Membrane; Single-pass type I membrane protein.
Tissue specificity: Widely expressed.
Induction: By EGF.
Post-translational: Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation (By similarity).
Sequence similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 15 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.
General information above from UniProt

LRIG1 Alternative Name

DKFZp586O1624,LIG1,LRIG1,LIG-1, [human]
D6Bwg0781e,LIG-1,Lrig1,Img, [mouse]

LRIG1 Related Studies

  • Shattuck DL, et al. (2007) LRIG1 Is a Novel Negative Regulator of the Met Receptor and Opposes Met and Her2 Synergy. Mol Cell Biol. 27 (5): 1934-46.
  • Ledda F, et al. (2008) Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF. J Neurosci. 28(1): 39-49.
  • Hedman H, et al. (2002) Is LRIG1 a tumour suppressor gene at chromosome 3p14.3 Acta Oncol. 41(4): 352-4.
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