All LMNA reagents are produced in house and quality controlled, including 1 LMNA Antibody, 30 LMNA Gene, 2 LMNA qPCR. All LMNA reagents are ready to use.
LMNA antibodies are validated with different applications, which are WB, ICC/IF, IF.
LMNA cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each LMNA of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Mutations of the LMNA gene encoding the lamin A and C nuclear envelope proteins cause an autosomal dominant form of dilated cardiomyopathy (DCM) with atrioventricular block (AVB). LMNA mutations can also lead to several other disorders, collectively termed laminopathies, involving heart, fat, nerve, bone, and skin tissues, and some premature ageing syndromes.Mutations of the LMNA gene have been shown to cause an autosomal dominant form of insulin resistance with familial partial lipodystrophy (PLD), frequently accompanied by diabetes. LMNA mutations are considered to be a rare cause of monogenic diabetes; however, they are probably sometimes misdiagnosed as type 2 diabetes (T2DM).