LMAN2 / VIP36 Protein

Lectin, mannose-binding 2 / Vesicular integral-membrane protein 36

LMAN2 / VIP36 Products

LMAN2 / VIP36 Protein, Recombinant

Molecule	Species	Description	Cat. No
LMAN2/VIP36	Human	LMAN2/VIP36 Protein, Recombinant	12455-H08E

LMAN2 / VIP36 Alternative Names

LMAN2, VIP36, C5orf8, GP36B [Homo sapiens]

Lman2, VIP36, 1110003H06Rik, 1300009F09Rik, AA408240, AL023023, AU040819, GP36B [Mus musculus]

LMAN2 / VIP36 Background

LMAN2 (Lectin, mannose-binding 2), also known as 36 kDa vesicular-integral membrane protein, VIP36, is an integral membrane protein previously isolated from epithelial MDCK cells, is an intracellular lectin of the secretory pathway. Overexpressed VIP36 had been localised to the Golgi complex, plasma membrane and endocytic structures suggesting post-Golgi trafficking of this molecule. LMAN2/VIP36 belongs to a family of animal lectins and may act as a cargo receptor. VIP36 is involved in the post-Golgi secretory pathway, suggesting that VIP36 plays a role in trafficking and sorting of secretory and/or membrane proteins during granule formation. As an intracellular lectin, LMAN2/VIP36 cycles between the endoplasmic reticulum (ER) and the Golgi apparatus, and is thought to act as a cargo receptor in the transport and sorting of glycoproteins. The interaction of VIP36 and immunoglobulin-binding protein (BiP) is not due to chaperone-substrate complex.

LMAN2 / VIP36 Related Studies

1. Nawa D, et al. (2007) Stable interaction of the cargo receptor VIP36 with molecular chaperone BiP. Glycobiology. 17(9): 913-21.
2. Shimada O, et al. (2003) Localization of VIP36 in the post-Golgi secretory pathway also of rat parotid acinar cells. J Histochem Cytochem. 51(8): 1057-63.
3. Hara-Kuge S, et al. (1999) Vesicular-integral membrane protein, VIP36, recognizes high-mannose type glycans containing alpha1-->2 mannosyl residues in MDCK cells. Glycobiology. 9(8): 833-9.
4. Fullekrug J, et al. (1999) VIP36 localisation to the early secretory pathway. J Cell Sci. 112 ( Pt 17): 2813-21.