LIFR Protein & Antibody (CD118)

Leukemia Inhibitory Factor Receptor alpha

LIFR Products

LIFR Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
LIFR/CD118	Human	LIFR/CD118 Protein, Recombinant	10628-H08H
LIFR/CD118	Mouse	LIFR/CD118 Protein, Recombinant	50423-M08H
LIFR/CD118	Rat	LIFR Protein, Recombinant	80322-R08H

LIFR Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human LIFR/CD118	WB, ELISA	Mouse Monoclonal Antibody	10628-MM07
Human LIFR/CD118	WB, ELISA	Rabbit Monoclonal Antibody	10628-R001
Human LIFR/CD118	WB, ELISA	Rabbit Polyclonal Antibody	10628-RP01
Human LIFR/CD118	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10628-RP02
Mouse LIFR/CD118	WB, ELISA	LIFR/CD118 Antibody, Rabbit PAb	50423-RP01
Mouse LIFR/CD118	WB, ELISA	LIFR/CD118 Antibody, Rabbit PAb (Antigen Affinity Purified)	50423-RP02

LIFR cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
LIFR/CD118	Human	Homo sapiens LIFR/CD118 cDNA Clone	HG10628-M
LIFR/CD118	Mouse	Mus musculus LIFR/CD118 cDNA Clone	MG50423-M
LIFR/CD118	Rat	Rat LIFR Gene cDNA Clone / ORF Clone	RG80322-G
LIFR/CD118	Cynomolgus	Cynomolgus monkey LIFR Gene cDNA Clone / ORF Clone	CG90210-G

LIFR Alternative Names

LIFR, CD118, FLJ98106, FLJ99923, LIF-R, SJS2, STWS, SWS

LIFR Related Areas

Neuroscience>>Neurotrophic Factor & Receptor>>Other Neurotrophic Factors & Receptors>>LIFR/CD118

Immunology>>Cytokine & Receptor>>Interleukin & Receptor >>IL-6 Family & Receptor>>LIFR/CD118

Immunology>>Cluster of Differentiation>>Other>>LIFR/CD118

LIFR Background

LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus affects the differentiation, proliferation, and survival of a wide variety of cells in the adult and the embryo. Besides LIF, LIFR can also bind to and activate CNTF (ciliary neurotrophic factor) and CLC (cardiotrophin like cytokine). Evidence showed that in the retina, LIFR activating LIF, CT-1 and cardiotrophin like cytokine (CLC) are strongly upregulated in response to preconditioning with bright cyclic light leading to robust activation of signal transducer and activator of transcription-3 (STAT3) in a time-dependent manner. Further, blocking LIFR activation during preconditioning using a LIFR antagonist (LIF05) attenuated the induced STAT3 activation and also resulted in reduced preconditioning-induced protection of the retinal photoreceptors. These data demonstrate that LIFR and its ligands play an essential role in endogenous neuroprotective mechanisms triggered by preconditioning-induced stress. LIFR was newly found to be a suppressor of hepatocellular carcinoma (HCC), one of the world's top five causes of cancer-related deaths.

LIFR Related Studies

Giese B, et al. (2005) Dimerization of the cytokine receptors gp130 and LIFR analysed in single cells. J Cell Sci. 118(Pt 21):5129-40.
Chollangi S, et al. (2009) Preconditioning-induced protection from oxidative injury is mediated by leukemia inhibitory factor receptor (LIFR) and its ligands in the retina. Neurobiol Dis. 4(3):535-44.
Okamura Y, et al. (2010) Leukemia inhibitory factor receptor (LIFR) is detected as a novel suppressor gene of hepatocellular carcinoma using double-combination array. Cancer Lett. 289(2):170-7.