Anti-LIFR Antibody

Cat: 10628-RP01
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Anti-LIFR Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-LIFR Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human LIFR
Immunogen
Recombinant Human LIFR protein (Catalog#10628-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human LIFR / CD118 (rh LIFR; Catalog#10628-H08H; NP_001121143.1; Met 1-Ser 833). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-LIFR Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-LIFR Antibody Alternative Names
Anti-CD118 Antibody;Anti-LIF-R Antibody;Anti-SJS2 Antibody;Anti-STWS Antibody;Anti-SWS Antibody
LIFR Background Information

LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus affects the differentiation, proliferation, and survival of a wide variety of cells in the adult and the embryo. Besides LIF, LIFR can also bind to and activate CNTF (ciliary neurotrophic factor) and CLC (cardiotrophin like cytokine). Evidence showed that in the retina, LIFR activating LIF, CT-1 and cardiotrophin like cytokine (CLC) are strongly upregulated in response to preconditioning with bright cyclic light leading to robust activation of signal transducer and activator of transcription-3 (STAT3) in a time-dependent manner. Further, blocking LIFR activation during preconditioning using a LIFR antagonist (LIF05) attenuated the induced STAT3 activation and also resulted in reduced preconditioning-induced protection of the retinal photoreceptors. These data demonstrate that LIFR and its ligands play an essential role in endogenous neuroprotective mechanisms triggered by preconditioning-induced stress. LIFR was newly found to be a suppressor of hepatocellular carcinoma (HCC), one of the world's top five causes of cancer-related deaths.

Full Name
leukemia inhibitory factor receptor alpha
References
  • Gearing, D.P. et al.,1991, EMBO J. 10 (10): 2839-2848.
  • Gearing, D.P. et al.,1992, New Biol. 4 (1): 61-65.
  • Mosley, B. et al.,1996, J. Biol. Chem. 271 (51): 32635-32643.
  • Timmermann, A. et al.,2002, Eur. J. Biochem. 269 (11): 2716-2726.
  • Lass, A. et al.,2002, Fertil. Steril. 76 (6): 1091-1096.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-LIFR Antibody Rabbit Polyclonal WB,ELISA 80322-T48
    Anti-LIFR Antibody Mouse Monoclonal ELISA(Cap) 80322-MM04
    Anti-LIFR Antibody Mouse Monoclonal ELISA 80322-MM07
    Anti-LIFR Antibody Rabbit Polyclonal ELISA 50423-RP02
    Anti-LIFR Antibody Rabbit Polyclonal ELISA 50423-T16
    Anti-LIFR Antibody Rabbit Monoclonal ELISA 50423-R110
    Anti-LIFR Antibody Rabbit Polyclonal ELISA 50423-RP01
    Anti-LIFR Antibody Mouse Monoclonal ELISA,IHC-P 10628-MM07
    Anti-LIFR Antibody Rabbit Monoclonal ELISA,IHC-P 10628-R001
    Anti-LIFR Antibody Rabbit Polyclonal ELISA 10628-RP02
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