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Leukemia Inhibitory Factor/LIF  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: Human Cells  
  • Slide 1
14890-H08H-5
14890-H08H-20
14890-H08H-100
5 µg 
20 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
  • Slide 1
14890-H02H-5
14890-H02H-20
14890-H02H-100
5 µg 
20 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
14890-HNAH-50
14890-HNAH-20
50 µg 
20 µg 
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Description:   
Expression host: Human Cells  
  • Slide 1
50756-MNAH-5
50756-MNAH-20
50756-MNAH-100
5 µg 
20 µg 
100 µg 
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Leukemia Inhibitory Factor/LIF Related Pathways

    Leukemia Inhibitory Factor/LIF Related Protein, Antibody, cDNA Gene, and ELISA Kits

    Leukemia Inhibitory Factor/LIF Related Protein, Antibody, cDNA Gene, and ELISA Kits

    Leukemia Inhibitory Factor/LIF Summary & Protein Information

    Leukemia Inhibitory Factor/LIF Background

    Gene Summary: The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
    General information above from NCBI
    Subcellular location: Secreted.
    Sequence similarity: Belongs to the LIF/OSM family.
    General information above from UniProt

    Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the IL-6 family of cytokines. It’s involved in growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation. LIF has potent proinflammatory property, being the inducer of the acute phase protein synthesis and affecting the cell recruitment into the area of damage or inflammation. LIF is also one of the cytokines that are capable to regulate the differentiation of embryonic stem cells, hematopoietic and neuronal cells. LIF binds to the specific LIF receptor (LIFR-α) which forms a heterodimer with a specific subunit common to all members of that family of receptors, the GP130 signal transducing subunit. This leads to activation of the JAK/STAT and MAPK cascades. Due to its polyfunctional activities, LIF is involved in the pathogenic events and development of many diseases of various origin.

    Leukemia Inhibitory Factor/LIF Alternative Name

    CDF,DIA,HILDA,MLPLI, [homo-sapiens]
    d factor,OTTMUSP00000005253,RP23-329P17.1, [human]

    Leukemia Inhibitory Factor/LIF Related Studies

  • Salas EM, et al. (2011) LIF, a Novel STAT5-Regulated Gene, Is Aberrantly Expressed in Myeloproliferative Neoplasms. Genes Cancer. 2 (5): 593-6.
  • Chodorowska G, et al. (2004) Leukemia inhibitory factor (LIF) and its biological activity. Ann Univ Mariae Curie Sklodowska Med. 59 (2): 189-93.
  • Garcia-Campana AM, et al. (2007) LIF detection of peptides and proteins in CE. Electrophoresis. 28 (1-2): 208-32.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"