All LIF reagents are produced in house and quality controlled, including 5 LIF Antibody, 39 LIF Gene, 1 LIF IPKit, 3 LIF Lysate, 5 LIF Protein, 2 LIF qPCR. All LIF reagents are ready to use.
Recombinant LIF proteins are expressed by HEK293 Cells with fusion tags as Native, C-human IgG1-Fc, C-His.
LIFantibodies are validated with different applications, which are ELISA, WB, IP.
LIFcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each LIF of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the IL-6 family of cytokines. It’s involved in growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation. LIF has potent proinflammatory property, being the inducer of the acute phase protein synthesis and affecting the cell recruitment into the area of damage or inflammation. LIF is also one of the cytokines that are capable to regulate the differentiation of embryonic stem cells, hematopoietic and neuronal cells. LIF binds to the specific LIF receptor (LIFR-α) which forms a heterodimer with a specific subunit common to all members of that family of receptors, the GP130 signal transducing subunit. This leads to activation of the JAK/STAT and MAPK cascades. Due to its polyfunctional activities, LIF is involved in the pathogenic events and development of many diseases of various origin.