LGALS8 / Galectin-8 Protein Price Inquiry ( Available Sizes )
LGALS8 / Galectin-8 Protein Product Information
||LGALS8,RP11-385F5.1, Gal-8, PCTA-1, PCTA1, Po66-CBP
||A DNA sequence encoding human LGALS8 (AAF19370.1) (Met 1-Trp 317) was expressed and purified.
LGALS8 / Galectin-8 Protein QC Testing
||>97% as determined by SDS-PAGE.
LGALS8 / Galectin-8 protein
||Measured by its ability to agglutinate human red blood cells.
The ED50 for this effect is typically 0.8-4 μg/ml.
||Please contact us for more information.
||Samples are stable for up to twelve months from date of receipt at -70℃
|Predicted N terminal:
||The recombinant human LGALS8 consists of 316 amino acids and predicts a molecular mass of 35.5 kDa. The apparent molecular mass of rhLGALS8/GST is approximately 34 KDa in SDS-PAGE under reducing conditions.
||Lyophilized from sterile PBS, pH7.4
- Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
- Please contact us for any concerns or special requirements.
LGALS8 / Galectin-8 Protein Usage Guide
||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
LGALS8 / Galectin-8 Protein Related Products & Topics
LGALS8 / Galectin-8 Protein Description
Galectin-8, also known as Gal-8, Po66 carbohydrate-binding protein, Prostate carcinoma tumor antigen 1, PCTA-1 and LGALS8, is a member of the galectin family. Galectin-8 / LGALS8 was discovered in prostate cancer cells and has been studied extensively in the last few years. Various studies showed that galectin-8 is widely expressed in tumor tissues as well as in normal tissues. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. Galectin-8 / LGALS8 is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. The level of galectin-8 expression may correlate with the malignancy of human colon cancers and the degree of differentiation of lung squamous cell carcinomas and neuro-endocrine tumors. The differences in Galectin-8 / LGALS8 expression levels between normal and tumor tissues have been used as a guide for the selection of strategies for the prevention and treatment of lung squamous cell carcinoma. Galectin-4, Galectin-8 represents a subfamily of galectins consisting of a tandem repeat of structurally different carbohydrate recognition domains within a single polypeptide chain.
- Hadari YR. et al., 1995, J Biol Chem. 270 (7): 3447-53.
- Bidon N. et al., 2001, Int J Mol Med. 8 (3): 245-50.
- Nishi N. et al., 2003, Glycobiology. 13 (11): 7 55-63.
- Bidon-Wagner N. et al., 2004, Glycoconj J. 19 (7-9): 557-63.