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LFA-3 / CD58  Protein

All LFA-3 Reagents

Expression host: Human Cells  
  • Slide 1
12409-H02H-50
12409-H02H-100
50 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
12409-H08H-50
12409-H08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
90190-C08H-50
90190-C08H-100
50 µg 
100 µg 
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LFA-3 / CD58 Related Pathways

    LFA-3 / CD58 Summary & Protein Information

    LFA-3 / CD58 Background

    Gene Summary: This gene encodes a member of the immunoglobulin superfamily. LFA-3 is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. LFA-3 is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
    General information above from NCBI
    Subunit structure: Interacts with CD2.
    Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein.
    Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor.
    Sequence similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.C
    General information above from UniProt

    CD53 is a member of the transmembrane 4 superfamily, also called the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD53 is a cell surface glycoprotein that is known to complex with integrins. Familial deficiency of CD53 gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. CD53 contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation.

    LFA-3 / CD58 Alternative Name

    LFA3, [Cynomolgus]
    ag3,CD58,CD58 antigen,CD58 molecule,LFA3,LFA-3,lymphocyte function-associated antigen 3,RP5-1086K13.2,surface glycoprotein LFA-3, [human]

    LFA-3 / CD58 Related Studies

  • Rochelle JM. et al., 1993, Int Immunol. 5 (2): 209-16.
  • Virtaneva KI. et al., 1993, Immunogenetics. 37 (6): 461-5.
  • Horejsí V. et al., 1991, FEBS Lett. 288 (1-2): 1-4.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"