Anti-LDLR Antibody (FITC)

Cat: 50305-R032-F
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Anti-LDLR Antibody (FITC) (Rabbit Monoclonal antibody) General Information
Product name
Anti-LDLR Antibody (FITC)
Validated applications
FCM
Species reactivity
Reacts with: Mouse
Specificity
Mouse LDLR
Immunogen
Recombinant Mouse LDLR / LDL Receptor protein (Catalog#50305-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse LDLR / LDL Receptor (rM LDLR / LDL Receptor; Catalog#50305-M08H; NP_034830.2; Met 1-Arg 790) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Source
Monoclonal Rabbit IgG Clone #032
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
FITC
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-LDLR Antibody (FITC) (Rabbit Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-LDLR Antibody (FITC) (Rabbit Monoclonal antibody) Images
Mouse LDLR/LDL R/LDL Receptor Flow Cytometry (FC) 2569
Profile of anti-LDLR reactivity on Raw264.7 cells analyzed by flow cytometry. Cells should be Fc-blocked by treatment with Mouse BD Fc Block™ purified anti-CD16/CD32 mAb 2.4G2 (Cat. No. 553141) prior to staining, washed, then stained with PerCP Rabbit anti-LDLR.
Anti-LDLR Antibody (FITC) Alternative Names
Anti-Hlb301 Antibody
LDLR Background Information

LDL Receptor, also known as LDLR, is a mosaic protein which belongs to the Low density lipoprotein receptor gene family. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL Receptor consists of 840 amino acids (after removal of signal peptide) and mediates the endocytosis of cholesterol-rich LDL. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. LDL Receptor is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants.

Full Name
low density lipoprotein receptor
References
  • Yamamoto T, et al. (1984) The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell. 39(1): 27-38.
  • Mao B, et al. (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature. 411(6835): 321-5.
  • Pinson KI, et al. (2000) An LDL-receptor-related protein mediates Wnt signalling in mice. Nature. 407(6803): 535-8.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-LDLR Antibody Rabbit Polyclonal ELISA 50305-RP02
    Anti-LDLR Antibody Rabbit Polyclonal ELISA 50305-RP01
    Anti-LDLR Antibody Rabbit Polyclonal ELISA,IHC-P 50305-T24
    Anti-LDLR Antibody (PerCP) Rabbit Monoclonal FCM 50305-R032-C
    Anti-LDLR Antibody (PE) Rabbit Monoclonal FCM 50305-R032-P
    Anti-LDLR Antibody Rabbit Monoclonal ELISA,FCM,ICC/IF,IF 50305-R032
    Anti-LDLR Antibody Rabbit Polyclonal ELISA 10231-RP01
    Anti-LDLR Antibody Rabbit Monoclonal ELISA 10231-R202
    Anti-LDLR Antibody Rabbit Monoclonal ELISA 10231-R101
    Anti-LDLR Antibody Rabbit Polyclonal ELISA 10231-RP02
    Anti-LDLR Antibody (PE) Rabbit Monoclonal FCM 10231-R301-P
    Anti-LDLR Antibody Mouse Monoclonal ELISA 10231-MM05
    Anti-LDLR Antibody Mouse Monoclonal ELISA(Det) 10231-MM12
    Anti-LDLR Antibody Mouse Monoclonal ELISA(Cap) 10231-MM02
    Anti-LDLR Antibody (APC) Rabbit Monoclonal FCM 10231-R301-A
    Anti-LDLR Antibody (FITC) Rabbit Monoclonal FCM 10231-R301-F
    Anti-LDLR Antibody Rabbit Monoclonal FCM 10231-R301
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