LDL Receptor Protein & Antibody (LDLR)

 Low Density Lipoprotein Receptor

LDL Receptor Products

LDL Receptor Protein, Recombinant

Molecule	Species	Description	Cat. No
LDL Receptor	Human	LDL Receptor/LDLR Protein, Recombinant	10231-H08H
LDL Receptor	Mouse	LDL Receptor/LDLR Protein, Recombinant	50305-M08H

  10231-H08H:

1. Immobilized human PCSK9 at 10 µg/mL (100 µl/well) can bind biotinylated recombinant human LDLR. The EC₅₀ of biotinylated human LDLR is 0.61 µg/mL. Measure by its ability to bind with human PCSK9 in a functional ELISA.

2. Immobilized mouse PCSK9 at 10 µg/mL (100 µl/well) can bind biotinylated recombinant human LDLR. The EC₅₀ of biotinylated human LDLR is 0.12 µg/mL. Measured by its binding ability in a functional ELISA.

  50305-M08H: The EC₅₀ of biotinylated mouse LDLR is 0.173 µg/mL. Measured by its binding ability in a functional ELISA. Immobilized Rat PCSK9 at 10 µg/mL (100 µl/well) can bind biotinylated recombinant mouse LDLR.

LDL Receptor Antibody

Molecule	Application	Description	Cat. No
Human LDL Receptor	WB, ELISA	LDL Receptor Antibody, Mouse MAb	10231-MM05
Human LDL Receptor	WB, ELISA	LDL Receptor Antibody, Rabbit Mab	10231-R101
Human LDL Receptor	WB, ELISA	LDL Receptor Antibody, Rabbit Mab	10231-R202
Human LDL Receptor	WB, ELISA	Rabbit Polyclonal Antibody	10231-RP01
Human LDL Receptor	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10231-RP02
Mouse LDL Receptor	WB, ELISA	LDL Receptor Antibody, Rabbit MAb	50305-R032
Mouse LDL Receptor	WB, ELISA	LDL Receptor Antibody, Rabbit PAb	50305-RP01
Mouse LDL Receptor	WB, ELISA	LDL Receptor Antibody, Rabbit PAb (Antigen Affinity Purified)	50305-RP02

LDL Receptor cDNA Clone

Molecule	Species	Description	Cat. No
LDL Receptor	Human	Homo sapiens LDL Receptor/LDLR cDNA Clone(NM_000527.3)	HG10231-M
LDL Receptor	Mouse	Mus musculus LDL Receptor/LDLR cDNA Clone	MG50481-M

LDL Receptor Related Areas

Immunology>>Innate Immunity>>Monocyte/Macrophage>>Scavenger Receptor>>LDL Receptor

Cardiovascular>>Lipid Metabolism>>LDL Receptor

LDL Receptor Alternative Names

LDLR, FH, FHC, LDLCQ2

LDL Receptor Background

LDL Receptor, also known as LDLR, is a mosaic protein which belongs to the Low density lipoprotein receptor gene family. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL Receptor consists of 840 amino acids (after removal of signal peptide) and mediates the endocytosis of cholesterol-rich LDL. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. LDL Receptor is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants.

LDL Receptor Related Studies

1. Yamamoto T, et al. (1984) The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell. 39(1): 27-38.
2. Mao B, et al. (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature. 411(6835): 321-5.
3. Pinson KI, et al. (2000) An LDL-receptor-related protein mediates Wnt signalling in mice. Nature. 407(6803): 535-8.