Anti-LDLR Antibody (PE)

Cat: 10231-R301-P
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Anti-LDLR Antibody (PE) (Rabbit Monoclonal antibody) General Information
Product name
Anti-LDLR Antibody (PE)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human LDLR
Immunogen
Recombinant Human LDL Receptor / LDLR protein (Catalog#10231-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human LDL Receptor / LDLR (rh LDL Receptor / LDLR; Catalog#10231-H08H; NP_000518.1; Met 1-Arg 788) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Source
Monoclonal Rabbit IgG Clone #301
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
PE
Concentration
5 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-LDLR Antibody (PE) (Rabbit Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-LDLR Antibody (PE) (Rabbit Monoclonal antibody) Images
Human LDLR/LDL R/LDL Receptor Flow Cytometry (FC) 2581
Profile of anti-Human LDLR reactivity on HepG2 cells analyzed by flow cytometry.
Anti-LDLR Antibody (PE) Alternative Names
Anti-FH Antibody;Anti-FHC Antibody;Anti-LDL R Antibody;Anti-LDL Receptor Antibody;Anti-LDLCQ2 Antibody
LDLR Background Information

LDL Receptor, also known as LDLR, is a mosaic protein which belongs to the Low density lipoprotein receptor gene family. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL Receptor consists of 840 amino acids (after removal of signal peptide) and mediates the endocytosis of cholesterol-rich LDL. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. LDL Receptor is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants.

Full Name
low density lipoprotein receptor
References
  • Yamamoto T, et al. (1984) The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell. 39(1): 27-38.
  • Mao B, et al. (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature. 411(6835): 321-5.
  • Pinson KI, et al. (2000) An LDL-receptor-related protein mediates Wnt signalling in mice. Nature. 407(6803): 535-8.
  • Product Description Host Clonality Application Catalog# (PDF)
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    Anti-LDLR Antibody (PerCP) Rabbit Monoclonal FCM 50305-R032-C
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    Anti-LDLR Antibody Mouse Monoclonal ELISA 10231-MM05
    Anti-LDLR Antibody Mouse Monoclonal ELISA(Det) 10231-MM12
    Anti-LDLR Antibody (APC) Rabbit Monoclonal FCM 10231-R301-A
    Anti-LDLR Antibody Rabbit Monoclonal FCM 10231-R301
    Anti-LDLR Antibody (FITC) Rabbit Monoclonal FCM 10231-R301-F
    Anti-LDLR Antibody Mouse Monoclonal ELISA(Cap) 10231-MM02
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