Anti-LDLR Antibody

Cat: 50305-RP02
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Anti-LDLR Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-LDLR Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse LDLR
Immunogen
Recombinant Mouse LDLR protein (Catalog#50305-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse LDLR / LDL Receptor (rM LDLR; Catalog#50305-M08H; NP_034830.2; Met 1-Arg 790). LDLR specific IgG was purified by mouse LDLR affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-LDLR Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-LDLR Antibody Alternative Names
Anti-Hlb301 Antibody
LDLR Background Information

LDL Receptor, also known as LDLR, is a mosaic protein which belongs to the Low density lipoprotein receptor gene family. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL Receptor consists of 840 amino acids (after removal of signal peptide) and mediates the endocytosis of cholesterol-rich LDL. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. LDL Receptor is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants.

Full Name
low density lipoprotein receptor
References
  • Yamamoto T, et al. (1984) The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell. 39(1): 27-38.
  • Mao B, et al. (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature. 411(6835): 321-5.
  • Pinson KI, et al. (2000) An LDL-receptor-related protein mediates Wnt signalling in mice. Nature. 407(6803): 535-8.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-LDLR Antibody (FITC) Rabbit Monoclonal FCM 50305-R032-F
    Anti-LDLR Antibody Rabbit Polyclonal ELISA,IHC-P 50305-T24
    Anti-LDLR Antibody (PE) Rabbit Monoclonal FCM 50305-R032-P
    Anti-LDLR Antibody Rabbit Monoclonal ICC/IF,IF 50305-R004
    Anti-LDLR Antibody Rabbit Polyclonal ELISA 50305-RP01
    Anti-LDLR Antibody Rabbit Monoclonal ICC/IF,IF 50305-R101
    Anti-LDLR Antibody Rabbit Monoclonal ELISA,FCM,ICC/IF,IF 50305-R032
    Anti-LDLR Antibody (PerCP) Rabbit Monoclonal FCM 50305-R032-C
    Anti-LDLR Antibody Rabbit Polyclonal ELISA 10231-RP01
    Anti-LDLR Antibody Rabbit Monoclonal ELISA 10231-R202
    Anti-LDLR Antibody Rabbit Monoclonal ELISA 10231-R101
    Anti-LDLR Antibody Rabbit Polyclonal ELISA 10231-RP02
    Anti-LDLR Antibody (FITC) Rabbit Monoclonal FCM 10231-R301-F
    Anti-LDLR Antibody (APC) Rabbit Monoclonal FCM 10231-R301-A
    Anti-LDLR Antibody Rabbit Monoclonal FCM 10231-R301
    Anti-LDLR Antibody Mouse Monoclonal ELISA(Det) 10231-MM12
    Anti-LDLR Antibody Mouse Monoclonal ELISA(Cap) 10231-MM02
    Anti-LDLR Antibody (PE) Rabbit Monoclonal FCM 10231-R301-P
    Anti-LDLR Antibody Mouse Monoclonal ELISA 10231-MM05
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