Lipocalin 1 (LCN1)

Lipocalin 1 could play a role in taste reception. Lipocalin 1 could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Lipocalin 1 can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Lipocalin 1 exhibits an extremely wide ligand pocket.

Lipocalin 1 (LCN1) Related Areas

Enzyme>>Protease & Regulator>>Cysteine Protease & Regulator>>LCN1/Lipocalin 1

Cardiovascular>>Lipid Metabolism>>LCN1/Lipocalin 1

Lipocalin 1 (LCN1) Alternative Names

LCN1, Lipocalin 1, MGC71975, PMFA, TLC, TP, VEGP [Homo sapiens]

Summaries for Lipocalin 1 (LCN1)

Entrez Gene summary for LCN1:

This LCN1 gene encodes a member of the lipocalin family of small secretory proteins. Lipocalins are extracellular transport proteins that bind to a variety of hydrophobic ligands. Lipocalin 1 is the primary lipid binding protein in tears and is overproduced in response to multiple stimuli including infection and stress. Lipocalin 1 may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and two pseudogenes of this gene are also located on the long arm of chromosome 9. [provided by RefSeq, Nov 2011]

Wikipedia summary for Lipocalin 1:

Lipocalin-1 is a protein that in humans is encoded by the LCN1 gene. Lipocalin-1 by this gene belongs to the lipocalin family. Lipocalins are a group of extracellular proteins that are able to bind lipophiles by enclosure within their structures to minimize solvent contact. Lipocalin-1 may bind hydrophobic ligands and inhibit cysteine proteinases. Lipocalin-1 may also play a role in taste reception.

Human Lipocalin 1 (LCN1) Protein General Information

 

• Protein names: Lipocalin-1
• Sequence length: 176 AA.
• Sequence similarities: Lipocalin 1 belongs to the calycin superfamily. Lipocalin family.
• Subunit structure: Homodimer. Lipocalin 1 binds to LMBR1L which may mediate its endocytosis.
• Subcellular location: Secreted.
• Tissue specificity: Lipocalin 1 is mainly expressed in lachrymal and salivary glands. Lipocalin 1 is also expressed in the prostate.

General information above from UniProt

Function for Lipocalin 1 (LCN1) Protein

UniProtKB:

Lipocalin 1 could play a role in taste reception. Lipocalin 1 could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Lipocalin 1 can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Lipocalin 1 exhibits an extremely wide ligand pocket.

Genatlas:

• Lipocalin 1 is involved in the transport of hydrophobic ligands