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LAMP2/CD107b  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
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Expression host: Human Cells  
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Expression host: Human Cells  
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90208-C08H-50
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LAMP2/CD107b Related Pathways

LAMP2/CD107b Related Protein, Antibody, cDNA Gene, and ELISA Kits

LAMP2/CD107b Related Protein, Antibody, cDNA Gene, and ELISA Kits

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LAMP2/CD107b Summary & Protein Information

LAMP2/CD107b Background

Gene Summary: The protein encoded by this LAMP2 gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. LAMP2 may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this LAMP2 gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
General information above from NCBI
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane.
Tissue specificity: Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver.
Post-translational: O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.
Involvement in disease: Danon disease (DAND) [MIM:300257]: DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarity: Belongs to the LAMP family.
General information above from UniProt

LAMP2 (Lysosomal-associated membrane protein 2), also known as CD107b (Cluster of Differentiation 107b), is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. In human, LAMP2, the causative gene of Danon disease, located on chromosome Xq24, encodes the lysosome-associated membrane protein-2 (LAMP-2). LAMP-2 deficiency, or Danon disease, is a rare X-linked lysosomal disease characterized by cardiomyopathy, vacuolar myopathy, and mental retardation. LAMP2 cardiomyopathy is an X-linked and highly progressive myocardial storage disorder associated with diminished survival, which clinically resembles sarcomeric hypertrophic cardiomyopathy.

LAMP2/CD107b Alternative Name

LAMPB,CD107b,LAMP-2,LGP110, [homo-sapiens]
CD107b,LAMPB,LAMP2,LGP110, [human]
CD107b,LAMP2,Lamp-2,Lamp-2a,Lamp-2b,Lamp-2c,Mac3,RP23-193O17.2, [mouse]
Mac3,LGP-B,CD107b,Lamp-2,LampII,Lamp-2a,Lamp-2b,Lamp-2c, [mus-musculus]

LAMP2/CD107b Related Studies

  • Maron BJ, et al. (2010) Profound left ventricular remodeling associated with LAMP2 cardiomyopathy. Am J Cardiol. 106(8): 1194-6.
  • Di Blasi C, et al. (2008) Danon disease: a novel LAMP2 mutation affecting the pre-mRNA splicing and causing aberrant transcripts and partial protein expression. Neuromuscul Disord. 18(12): 962-6.
  • Echaniz-Laguna A, et al. (2006) Novel Lamp-2 gene mutation and successful treatment with heart transplantation in a large family with Danon disease. Muscle Nerve. 33(3): 393-7.
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