LAMP2 / CD107b Protein

Lysosomal-associated membrane protein 2 / Cluster of Differentiation 107b

LAMP2 / CD107b Products

LAMP2 / CD107b Protein, Recombinant

Molecule	Species	Description	Cat. No
LAMP2/CD107b	Mouse	LAMP2/CD107b Protein, Recombinant	50791-M08H

LAMP2 / CD107b cDNA Clone

Molecule	Species	Description	Cat. No
LAMP2/CD107b	Mouse	Mouse LAMP2/CD107b cDNA Clone / ORF Clone	MG50791-G

LAMP2 / CD107b Related Areas

Immunology>>Cluster of Differentiation>>Other>>LAMP2/CD107b

LAMP2 / CD107b Alternative Names

LAMP2, CD107b, LAMPB, LGP110 [Homo sapiens]

LAMP2, CD107b, RP23-193O17.2, Lamp-2, Lamp-2a, Lamp-2b, Lamp-2c, Mac3 [Mus musculus]

LAMP2 / CD107b Background

LAMP2 (Lysosomal-associated membrane protein 2), also known as CD107b (Cluster of Differentiation 107b), is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. In human, LAMP2, the causative gene of Danon disease, located on chromosome Xq24, encodes the lysosome-associated membrane protein-2 (LAMP-2). LAMP-2 deficiency, or Danon disease, is a rare X-linked lysosomal disease characterized by cardiomyopathy, vacuolar myopathy, and mental retardation. LAMP2 cardiomyopathy is an X-linked and highly progressive myocardial storage disorder associated with diminished survival, which clinically resembles sarcomeric hypertrophic cardiomyopathy.

LAMP2 / CD107b Related Studies

1. Maron BJ, et al. (2010) Profound left ventricular remodeling associated with LAMP2 cardiomyopathy. Am J Cardiol. 106(8): 1194-6.
2. Di Blasi C, et al. (2008) Danon disease: a novel LAMP2 mutation affecting the pre-mRNA splicing and causing aberrant transcripts and partial protein expression. Neuromuscul Disord. 18(12): 962-6.
3. Echaniz-Laguna A, et al. (2006) Novel Lamp-2 gene mutation and successful treatment with heart transplantation in a large family with Danon disease. Muscle Nerve. 33(3): 393-7.