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LAMP-1/CD107a/LAMP1 Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active
Expression host: Human Cells
  • Slide 1
11215-H08H-50
11215-H08H-100
50 µg / $178
100 µg / $298
Add to Cart
Expression host: Human Cells
  • Slide 1
80226-R02H-50
80226-R02H-100
50 µg / $178
100 µg / $298
Add to Cart

LAMP-1/CD107a/LAMP1 Related Areas

LAMP-1/CD107a/LAMP1 Related Pathways

LAMP-1/CD107a/LAMP1 Related Product

    LAMP-1/CD107a/LAMP1 Summary & Protein Information

    LAMP-1/CD107a/LAMP1 Background

    Gene Summary: The protein encoded by this LAMP1 gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. LAMP-1 may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane. Co-localizes with OSBPL1A at the late endosome.
    Post-translational: O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans.
    Sequence similarity: Belongs to the LAMP family.C
    General information above from UniProt

    Lysosome-associated membrane glycoprotein 1, also known as CD107 antigen-like family member A, CD107a, and LAMP1, is a single-pass type I membrane protein which belongs to the LAMP family. CD107a is expressed largely in the endosome-lysosome membranes of cells, but is also found on the plasma membrane (1-2% of total LAMP1). LAMP1 has been implicated in a variety of cellular functions, including cancer metastasis. It has been proposed LAMP1 serves as a therapeutic agent for some cancers, as well as a marker for lysosomal storage disorders and different cell types such as cytotoxic T cells. LAMP2, also known as CD107b, may also play a role in tumor cell metastasis and functions in the protection, maintenance, and adhesion of the lysosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation. LAMP-1 is a glycoprotein highly expressed in lysosomal membranes. The present study was initiated to test LAMP-1 mRNA and protein levels in post mortem frontal cortex (area 8) of Alzheimer's disease (AD) stages I-IIA/B and stages V-VIC of Braak and Braak, compared with age-matched controls. LAMP-1 occurred in microglia and multinucleated giant cells in one AD case in whom amyloid burden was cleared following betaA-peptide immunization. In addition, LAMP-1 has been suggested to be a cell surface receptor for a specific amelogenin isoform, leucine-rich amelogenin peptide or LRAP. LAMP-1 can serve as a cell surface binding site for amelogenin on dental follicle cells and cementoblasts.

    LAMP-1/CD107a/LAMP1 Alternative Name

    CD107a,LAMP1,LAMPA,LGP120, [human]
    AI196048,CD107a,Lamp1,LAMP-1, [mouse]

    LAMP-1/CD107a/LAMP1 Related Studies

  • Parkinson-Lawrence EJ, et al. (2005) Immunochemical analysis of CD107a (LAMP-1). Cell Immunol. 236(1-2): 161-6.
  • Barrachina M, et al. (2006) Lysosome-associated membrane protein 1 (LAMP-1) in Alzheimer's disease. Neuropathol Appl Neurobiol. 32(5): 505-16.
  • Zhang H, et al. (2010) Full length amelogenin binds to cell surface LAMP-1 on tooth root/periodontium associated cells. Arch Oral Biol. 55(6): 417-25.
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