LAMP-1 / CD107a Protein & Antibody (LAMP1)

Lysosomal-Associated Membrane Protein 1 / Cluster of Differentiation 107a

LAMP-1/CD107a/LAMP1 Products

LAMP-1/CD107a/LAMP1 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
LAMP-1/CD107a/LAMP1	Human	LAMP-1 / CD107a / LAMP1 Protein, Recombinant	11215-H08H
LAMP-1/CD107a/LAMP1	Rat	LAMP1 / CD107a / LAMP1 Protein, Recombinant	80226-R02H

LAMP-1/CD107a/LAMP1 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human LAMP-1/CD107a/LAMP1	WB, ELISA	LAMP-1 / CD107a / LAMP1 Mouse MAb	11215-MM07
Human LAMP-1/CD107a/LAMP1	WB, FCM	LAMP-1 / CD107a / LAMP1 Antibody ( FITC )	11215-MM07-F
Human LAMP-1/CD107a/LAMP1	WB, ELISA	LAMP-1 / CD107a / LAMP1 Antibody, Rabbit MAb	11215-R107
Human LAMP-1/CD107a/LAMP1	WB, ELISA	LAMP-1 / CD107a / LAMP1 Rabbit PAb	11215-RP01
Human LAMP-1/CD107a/LAMP1	WB, ELISA	LAMP-1 / CD107a / LAMP1 Rabbit PAb (Antigen Affinity Purified)	11215-RP02

LAMP-1/CD107a/LAMP1 ELISA Kits

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human LAMP-1/CD107a/LAMP1	ELISA	LAMP-1 / CD107a / LAMP1 ELISA Pair Set, Human ELISA Pair Set	SEK11215

LAMP-1/CD107a/LAMP1 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
LAMP-1/CD107a/LAMP1	Human	Homo sapiens LAMP-1 / CD107a / LAMP1 DNA ORF clone(NM_005561.3)	HG11215-M
LAMP-1/CD107a/LAMP1	Rat	Rat LAMP-1 / CD107a / LAMP1 DNA ORF clone	RG80226-G

LAMP-1/CD107a/LAMP1 Related Areas

Cancer>>Cancer Stem Cell (CSC)>>LAMP-1/CD107a

Immunology>>Innate Immunity>>Lysosomal Enzyme>>LAMP-1/CD107a

Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)>>LAMP-1/CD107a

Immunology>>Cluster of Differentiation>>Other>>LAMP-1/CD107a

LAMP-1/CD107a/LAMP1 Alternative Names

LAMP1, CD107a, LAMPA, LGP120 [Homo sapiens]

LAMP-1, CD107a, Lamp1, AI196048 [Mus musculus]

LAMP-1/CD107a/LAMP1 Background

Lysosome-associated membrane glycoprotein 1, also known as CD107 antigen-like family member A, CD107a, and LAMP1, is a single-pass type I membrane protein which belongs to the LAMP family. CD107a is expressed largely in the endosome-lysosome membranes of cells, but is also found on the plasma membrane (1-2% of total LAMP1). LAMP1 has been implicated in a variety of cellular functions, including cancer metastasis. It has been proposed LAMP1 serves as a therapeutic agent for some cancers, as well as a marker for lysosomal storage disorders and different cell types such as cytotoxic T cells. LAMP2, also known as CD107b, may also play a role in tumor cell metastasis and functions in the protection, maintenance, and adhesion of the lysosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation. LAMP-1 is a glycoprotein highly expressed in lysosomal membranes. The present study was initiated to test LAMP-1 mRNA and protein levels in post mortem frontal cortex (area 8) of Alzheimer's disease (AD) stages I-IIA/B and stages V-VIC of Braak and Braak, compared with age-matched controls. LAMP-1 occurred in microglia and multinucleated giant cells in one AD case in whom amyloid burden was cleared following betaA-peptide immunization. In addition, LAMP-1 has been suggested to be a cell surface receptor for a specific amelogenin isoform, leucine-rich amelogenin peptide or LRAP. LAMP-1 can serve as a cell surface binding site for amelogenin on dental follicle cells and cementoblasts.

LAMP-1/CD107a/LAMP1 Related Studies

1. Parkinson-Lawrence EJ, et al. (2005) Immunochemical analysis of CD107a (LAMP-1). Cell Immunol. 236(1-2): 161-6.
2. Barrachina M, et al. (2006) Lysosome-associated membrane protein 1 (LAMP-1) in Alzheimer's disease. Neuropathol Appl Neurobiol. 32(5): 505-16.
3. Zhang H, et al. (2010) Full length amelogenin binds to cell surface LAMP-1 on tooth root/periodontium associated cells. Arch Oral Biol. 55(6): 417-25.