LAMP-1 / CD107a Protein & Antibody (LAMP1)

Lysosomal-Associated Membrane Protein 1 / Cluster of Differentiation 107a

LAMP-1 / CD107a Products

LAMP-1 / CD107a Protein, Recombinant

Molecule	Species	Description	Cat. No
LAMP-1/CD107a	Human	LAMP-1/CD107a Protein, Recombinant	11215-H08H

LAMP-1 / CD107a Antibody

Molecule	Application	Description	Cat. No
Human LAMP-1/CD107a	WB, ELISA	Mouse Monoclonal Antibody	11215-MM07
Human LAMP-1/CD107a	WB, FCM	LAMP-1 / CD107a / LAMP1 Antibody ( FITC )	11215-MM07-F
Human LAMP-1/CD107a	WB, ELISA	LAMP-1/CD107a Antibody, Rabbit MAb	11215-R107
Human LAMP-1/CD107a	WB, ELISA	Rabbit Polyclonal Antibody	11215-RP01
Human LAMP-1/CD107a	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11215-RP02

LAMP-1 / CD107a ELISA Kits

Molecule	Application	Description	Cat. No
Human LAMP-1 / CD107a	ELISA	LAMP-1 / CD107a / LAMP1 ELISA Pair Set, Human ELISA Pair Set	SEK11215

LAMP-1 / CD107a cDNA Clone

Molecule	Species	Description	Cat. No
LAMP-1 / CD107a	Human	Homo sapiens LAMP-1/CD107a DNA ORF clone(NM_005561.3)	HG11215-M
LAMP-1 / CD107a	Rat	Rat LAMP-1/CD107a DNA ORF clone	RG80226-G

LAMP-1 / CD107a Related Areas

Cancer>>Cancer Stem Cell (CSC)>>LAMP-1/CD107a

Immunology>>Innate Immunity>>Lysosomal Enzyme>>LAMP-1/CD107a

Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)>>LAMP-1/CD107a

Immunology>>Cluster of Differentiation>>Other>>LAMP-1/CD107a

LAMP-1 / CD107a Alternative Names

LAMP1, CD107a, LAMPA, LGP120 [Homo sapiens]

LAMP-1, CD107a, Lamp1, AI196048 [Mus musculus]

LAMP-1 / CD107a Background

Lysosome-associated membrane glycoprotein 1, also known as CD107 antigen-like family member A, CD107a, and LAMP1, is a single-pass type I membrane protein which belongs to the LAMP family. CD107a is expressed largely in the endosome-lysosome membranes of cells, but is also found on the plasma membrane (1-2% of total LAMP1). LAMP1 has been implicated in a variety of cellular functions, including cancer metastasis. It has been proposed LAMP1 serves as a therapeutic agent for some cancers, as well as a marker for lysosomal storage disorders and different cell types such as cytotoxic T cells. LAMP2, also known as CD107b, may also play a role in tumor cell metastasis and functions in the protection, maintenance, and adhesion of the lysosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation. LAMP-1 is a glycoprotein highly expressed in lysosomal membranes. The present study was initiated to test LAMP-1 mRNA and protein levels in post mortem frontal cortex (area 8) of Alzheimer's disease (AD) stages I-IIA/B and stages V-VIC of Braak and Braak, compared with age-matched controls. LAMP-1 occurred in microglia and multinucleated giant cells in one AD case in whom amyloid burden was cleared following betaA-peptide immunization. In addition, LAMP-1 has been suggested to be a cell surface receptor for a specific amelogenin isoform, leucine-rich amelogenin peptide or LRAP. LAMP-1 can serve as a cell surface binding site for amelogenin on dental follicle cells and cementoblasts.

LAMP-1 / CD107a Related Studies

1. Parkinson-Lawrence EJ, et al. (2005) Immunochemical analysis of CD107a (LAMP-1). Cell Immunol. 236(1-2): 161-6.
2. Barrachina M, et al. (2006) Lysosome-associated membrane protein 1 (LAMP-1) in Alzheimer's disease. Neuropathol Appl Neurobiol. 32(5): 505-16.
3. Zhang H, et al. (2010) Full length amelogenin binds to cell surface LAMP-1 on tooth root/periodontium associated cells. Arch Oral Biol. 55(6): 417-25.