All LAMP1 reagents are produced in house and quality controlled, including 10 LAMP1 Antibody, 1 LAMP1 ELISA, 24 LAMP1 Gene, 3 LAMP1 IPKit, 2 LAMP1 Lysate, 2 LAMP1 Protein, 2 LAMP1 qPCR. All LAMP1 reagents are ready to use.
Recombinant LAMP1 proteins are expressed by HEK293 Cells with fusion tags as C-His, C-human IgG1-Fc.
LAMP1antibodies are validated with different applications, which are FCM, WB, ELISA, IHC-P, ICC/IF, IF, IP, ELISA(Cap), ELISA(Det).
LAMP1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each LAMP1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
LAMP1ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Lysosome-associated membrane glycoprotein 1, also known as CD107 antigen-like family member A, CD107a, and LAMP1, is a single-pass type I membrane protein which belongs to the LAMP family. CD107a is expressed largely in the endosome-lysosome membranes of cells, but is also found on the plasma membrane (1-2% of total LAMP1). LAMP1 has been implicated in a variety of cellular functions, including cancer metastasis. It has been proposed LAMP1 serves as a therapeutic agent for some cancers, as well as a marker for lysosomal storage disorders and different cell types such as cytotoxic T cells. LAMP2, also known as CD107b, may also play a role in tumor cell metastasis and functions in the protection, maintenance, and adhesion of the lysosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation. LAMP-1 is a glycoprotein highly expressed in lysosomal membranes. The present study was initiated to test LAMP-1 mRNA and protein levels in post mortem frontal cortex (area 8) of Alzheimer's disease (AD) stages I-IIA/B and stages V-VIC of Braak and Braak, compared with age-matched controls. LAMP-1 occurred in microglia and multinucleated giant cells in one AD case in whom amyloid burden was cleared following betaA-peptide immunization. In addition, LAMP-1 has been suggested to be a cell surface receptor for a specific amelogenin isoform, leucine-rich amelogenin peptide or LRAP. LAMP-1 can serve as a cell surface binding site for amelogenin on dental follicle cells and cementoblasts.