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LAMP-1 / CD107a Protein & Antibody (LAMP1)

Lysosomal-Associated Membrane Protein 1 / Cluster of Differentiation 107a

LAMP-1/CD107a/LAMP1 Products

LAMP-1/CD107a/LAMP1 Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
LAMP-1/CD107a/LAMP1 Human LAMP-1 / CD107a / LAMP1 Protein, Recombinant 11215-H08H
LAMP-1/CD107a/LAMP1 Rat LAMP1 / CD107a / LAMP1 Protein, Recombinant 80226-R02H

LAMP-1/CD107a/LAMP1 Antibody

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
LAMP-1/CD107a/LAMP1
WB, ELISA LAMP-1 / CD107a / LAMP1 Mouse MAb 11215-MM07
Human
LAMP-1/CD107a/LAMP1
WB, FCM LAMP-1 / CD107a / LAMP1 Antibody ( FITC ) 11215-MM07-F
Human
LAMP-1/CD107a/LAMP1
WB, ELISA LAMP-1 / CD107a / LAMP1 Antibody, Rabbit MAb 11215-R107
Human
LAMP-1/CD107a/LAMP1
WB, ELISA LAMP-1 / CD107a / LAMP1 Rabbit PAb 11215-RP01
Human
LAMP-1/CD107a/LAMP1
WB, ELISA LAMP-1 / CD107a / LAMP1 Rabbit PAb (Antigen Affinity Purified) 11215-RP02

LAMP-1/CD107a/LAMP1 ELISA Kits

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human LAMP-1/CD107a/LAMP1 ELISA LAMP-1 / CD107a / LAMP1 ELISA Pair Set, Human ELISA Pair Set SEK11215

LAMP-1/CD107a/LAMP1 cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
LAMP-1/CD107a/LAMP1 Human Homo sapiens LAMP-1 / CD107a / LAMP1 DNA ORF clone(NM_005561.3) HG11215-M
LAMP-1/CD107a/LAMP1 Rat Rat LAMP-1 / CD107a / LAMP1 DNA ORF clone RG80226-G

LAMP-1/CD107a/LAMP1 Related Areas

Cancer>>Cancer Stem Cell (CSC)>>LAMP-1/CD107a

Immunology>>Innate Immunity>>Lysosomal Enzyme>>LAMP-1/CD107a

Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)>>LAMP-1/CD107a

Immunology>>Cluster of Differentiation>>Other>>LAMP-1/CD107a

LAMP-1/CD107a/LAMP1 Alternative Names

LAMP1, CD107a, LAMPA, LGP120 [Homo sapiens]

LAMP-1, CD107a, Lamp1, AI196048 [Mus musculus]

LAMP-1/CD107a/LAMP1 Background

Lysosome-associated membrane glycoprotein 1, also known as CD107 antigen-like family member A, CD107a, and LAMP1, is a single-pass type I membrane protein which belongs to the LAMP family. CD107a is expressed largely in the endosome-lysosome membranes of cells, but is also found on the plasma membrane (1-2% of total LAMP1). LAMP1 has been implicated in a variety of cellular functions, including cancer metastasis. It has been proposed LAMP1 serves as a therapeutic agent for some cancers, as well as a marker for lysosomal storage disorders and different cell types such as cytotoxic T cells. LAMP2, also known as CD107b, may also play a role in tumor cell metastasis and functions in the protection, maintenance, and adhesion of the lysosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation. LAMP-1 is a glycoprotein highly expressed in lysosomal membranes. The present study was initiated to test LAMP-1 mRNA and protein levels in post mortem frontal cortex (area 8) of Alzheimer's disease (AD) stages I-IIA/B and stages V-VIC of Braak and Braak, compared with age-matched controls. LAMP-1 occurred in microglia and multinucleated giant cells in one AD case in whom amyloid burden was cleared following betaA-peptide immunization. In addition, LAMP-1 has been suggested to be a cell surface receptor for a specific amelogenin isoform, leucine-rich amelogenin peptide or LRAP. LAMP-1 can serve as a cell surface binding site for amelogenin on dental follicle cells and cementoblasts.

LAMP-1/CD107a/LAMP1 Related Studies

  1. Parkinson-Lawrence EJ, et al. (2005) Immunochemical analysis of CD107a (LAMP-1). Cell Immunol. 236(1-2): 161-6.
  2. Barrachina M, et al. (2006) Lysosome-associated membrane protein 1 (LAMP-1) in Alzheimer's disease. Neuropathol Appl Neurobiol. 32(5): 505-16.
  3. Zhang H, et al. (2010) Full length amelogenin binds to cell surface LAMP-1 on tooth root/periodontium associated cells. Arch Oral Biol. 55(6): 417-25.

 

 

LAMP-1 (CD107a, LAMP1) related areas, pathways, and other information

 

 

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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