LAMP-1 (CD107a, LAMP1)

Lysosome-associated membrane glycoprotein 1, also known as CD107 antigen-like family member A, CD107a, and LAMP-1, is a single-pass type I membrane protein which belongs to the LAMP family. CD107a is expressed largely in the endosome-lysosome membranes of cells, but is also found on the plasma membrane (1-2% of total LAMP1). LAMP-1 has been implicated in a variety of cellular functions, including cancer metastasis. It has been proposed LAMP-1 serves as a therapeutic agent for some cancers, as well as a marker for lysosomal storage disorders and different cell types such as cytotoxic T cells. LAMP2, also known as CD107b, may also play a role in tumor cell metastasis and functions in the protection, maintenance, and adhesion of the lysosome. Cell surface LAMP-1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation. LAMP-1 is a glycoprotein highly expressed in lysosomal membranes. The present study was initiated to test LAMP-1 mRNA and protein levels in post mortem frontal cortex (area 8) of Alzheimer's disease (AD) stages I-IIA/B and stages V-VIC of Braak and Braak, compared with age-matched controls. LAMP-1 occurred in microglia and multinucleated giant cells in one AD case in whom amyloid burden was cleared following betaA-peptide immunization. In addition, LAMP-1 has been suggested to be a cell surface receptor for a specific amelogenin isoform, leucine-rich amelogenin peptide or LRAP. LAMP-1 can serve as a cell surface binding site for amelogenin on dental follicle cells and cementoblasts.

LAMP-1 (CD107a, LAMP1) Related Areas

Cancer>>Cancer Stem Cell (CSC)>>LAMP-1/CD107a

Immunology>>Innate Immunity>>Lysosomal Enzyme>>LAMP-1/CD107a

Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)>>LAMP-1/CD107a

Immunology>>Cluster of Differentiation>>Other>>LAMP-1/CD107a

LAMP-1 (CD107a, LAMP1) Alternative Names

LAMP1, CD107a, LAMPA, LGP120 [Homo sapiens]

LAMP-1, CD107a, Lamp1, AI196048 [Mus musculus]

Summaries for LAMP-1 (CD107a, LAMP1)

Entrez Gene summary for LAMP1:

The protein encoded by this LAMP1 gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. LAMP-1 may also play a role in tumor cell metastasis.

Wikipedia summary for LAMP-1:

Lysosomal-associated membrane protein 1 (LAMP-1) also known as CD107a (Cluster of Differentiation 107a) , is a human gene. LAMP-1 has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells.

Human LAMP-1 (CD107a, LAMP1) Protein General Information

 

• Protein names: Lysosome-associated membrane glycoprotein 1, Short name = LAMP-1
• Sequence length: 417 AA.
• Sequence similarities: LAMP-1 belongs to the LAMP family.
• Post-translational modification: O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans.
• Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome. Note: LAMP-1 shuttles between lysosomes, endosomes, and the plasma membrane. Co-localizes with OSBPL1A at the late endosome.

General information above from UniProt

Function for LAMP-1 (CD107a, LAMP1) Protein

UniProtKB:

LAMP-1 presents carbohydrate ligands to selectins. LAMP-1 is also implicated in tumor cell metastasis.

Genatlas:

• LAMP-1 presents carbohydrate ligands to selectins
• LAMP-1 could be involved in keratinocyte differentiation, but apparently not through interaction with galectin-3
• LAMP-1 and LAMP2 are delivered to phagosomes during the maturation process (Pubmed 17245426)
• LAMP-1 can serve as a cell surface binding site for amelogenin on dental follicle cells and cementoblasts (Pubmed 20382373)

Homology for human LAMP-1 (CD107a, LAMP1)

• homolog to murine Lamp1

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