Reacts with: Human
Recombinant Human LAIR2 protein (Catalog#10868-H08H)
Produced in rabbits immunized with purified, recombinant Human LAIR2 (rhLAIR2; Catalog#10868-H08H; NP_002279.2; Met 1-Pro 152). Total IgG was purified by Protein A affinity chromatography.
Polyclonal Rabbit IgG
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD306 Antibody;Anti-LAIR2 Antibody;Anti-MGC71634 Antibody;Anti-XXbac-BCX535A19.6 Antibody
Leukocyte-associated immunoglobulin-like receptor 2 ( LAIR2 ), also known as CD306, is a 131 amino acid protein containing one lg-like C2-type domain. It is expressed as a soluble receptor exhibiting high affinity for various collagen molecules to which it binds in a hydroxyproline-dependent manner. LAIR2 is a member of the immunoglobulin superfamily and was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. LAIR2 is thought to be secreted and may help modulate mucosal tolerance. As a natural competitor for LAIR1, soluble LAIR2 prevents binding of human LAIR1 to collagens and LAIR1 cross-linking, thereby regulating its inhibitory potential. Accordingly, LAIR2 is suggested to perform an immunoregulatory function.
Meyaard, L. et al.,1997, Immunity.7:283-290. Meyaard, L. et al.,1999, J. Immunol. 162:5800-5804. Meyaard, L. et al., 2001, J. Exp. Med. 194 (1): 107-112. Meyaard, L., 2003, J Biol Regul Homeost Agents. 17 (4): 330-333. Lebbink, R. J. et al., 2008, J Immunol. 180 (3):1662-1669. Lebbink,R.J. et al., 2009, Matrix Biol. 28 (4):202-210.