Anti-LAIR2 Antibody

Cat: 10868-RP01
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Anti-LAIR2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-LAIR2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human LAIR2
Immunogen
Recombinant Human LAIR2 protein (Catalog#10868-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human LAIR2 (rhLAIR2; Catalog#10868-H08H; NP_002279.2; Met 1-Pro 152). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-LAIR2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-LAIR2 Antibody Alternative Names
Anti-CD306 Antibody;Anti-LAIR2 Antibody;Anti-MGC71634 Antibody;Anti-XXbac-BCX535A19.6 Antibody
LAIR2 Background Information

Leukocyte-associated immunoglobulin-like receptor 2 ( LAIR2 ), also known as CD306, is a 131 amino acid protein containing one lg-like C2-type domain. It is expressed as a soluble receptor exhibiting high affinity for various collagen molecules to which it binds in a hydroxyproline-dependent manner. LAIR2 is a member of the immunoglobulin superfamily and was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. LAIR2 is thought to be secreted and may help modulate mucosal tolerance. As a natural competitor for LAIR1, soluble LAIR2 prevents binding of human LAIR1 to collagens and LAIR1 cross-linking, thereby regulating its inhibitory potential. Accordingly, LAIR2 is suggested to perform an immunoregulatory function.

Full Name
leukocyte associated immunoglobulin like receptor 2
References
  • Meyaard, L. et al.,1997, Immunity.7:283-290.
  • Meyaard, L. et al.,1999, J. Immunol. 162:5800-5804.
  • Meyaard, L. et al., 2001,  J. Exp. Med. 194 (1): 107-112.
  • Meyaard, L., 2003, J Biol Regul Homeost Agents.  17 (4): 330-333.
  • Lebbink, R. J. et al., 2008, J Immunol. 180 (3):1662-1669.
  • Lebbink,R.J. et al., 2009,  Matrix Biol.  28 (4):202-210.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-LAIR2 Antibody Rabbit Monoclonal ELISA(Cap) 10868-R001
    Anti-LAIR2 Antibody Rabbit Monoclonal ELISA 10868-R024
    Anti-LAIR2 Antibody Rabbit Polyclonal ELISA 10868-RP02
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