Anti-LAIR2 Antibody (PE)
Reacts with: Human
Recombinant Human LAIR2 protein (Catalog#10868-H08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human LAIR2 (rh LAIR2; Catalog#10868-H08H; NP_002279.2; Met 1-Pro 152) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Monoclonal Rabbit IgG Clone #024
Aqueous solution containing 0.5% BSA and 0.1% sodium azide
5 μl/Test, 0.1 mg/ml
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-CD306 Antibody;Anti-LAIR2 Antibody;Anti-MGC71634 Antibody;Anti-XXbac-BCX535A19.6 Antibody
Leukocyte-associated immunoglobulin-like receptor 2 ( LAIR2 ), also known as CD306, is a 131 amino acid protein containing one lg-like C2-type domain. It is expressed as a soluble receptor exhibiting high affinity for various collagen molecules to which it binds in a hydroxyproline-dependent manner. LAIR2 is a member of the immunoglobulin superfamily and was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. LAIR2 is thought to be secreted and may help modulate mucosal tolerance. As a natural competitor for LAIR1, soluble LAIR2 prevents binding of human LAIR1 to collagens and LAIR1 cross-linking, thereby regulating its inhibitory potential. Accordingly, LAIR2 is suggested to perform an immunoregulatory function.
Meyaard, L. et al.,1997, Immunity.7:283-290. Meyaard, L. et al.,1999, J. Immunol. 162:5800-5804. Meyaard, L. et al., 2001, J. Exp. Med. 194 (1): 107-112. Meyaard, L., 2003, J Biol Regul Homeost Agents. 17 (4): 330-333. Lebbink, R. J. et al., 2008, J Immunol. 180 (3):1662-1669. Lebbink,R.J. et al., 2009, Matrix Biol. 28 (4):202-210.