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Leukocyte-associated Ig-like receptor 1 Protein Datasheet
LAIR1 Protein Price Inquiry ( Available Sizes )
LAIR1 Protein Product Information
|Protein Construction:||A DNA sequence encoding the mouse LAIR1 (Q8BG84-6)(Gln22-Ser133) was expressed, fused with the Fc region of human IgG1 at the C-terminus.|
|Expression Host:||Human Cells|
LAIR1 Protein QC Testing
|Purity:||> 95% as determined by SDS-PAGE||SDS-PAGE:
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Gln 22|
The recombinant mouse LAIR1 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 353 amino acids and has a predicted molecular mass of 39.6 kDa. The apparent molecular mass of the protein is approximately 49-53 kDa in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
LAIR1 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
LAIR1 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|LAIR1||Mouse||LAIR1 Protein, Recombinant||51030-M02H|
|LAIR1||Mouse||LAIR1 Protein, Recombinant||51030-M08H|
LAIR1 Protein Description
Leukocyte associated Ig-like receptor-1 (LAIR1) is a surface molecule expressed on human mononuclear leukocytes that functions as an inhibitory receptor on human NK cells. In addition to NK cells, LAIR1 is expressed on T cells, B cells, macrophages, and dendritic cells. It is predicted to mediate inhibitory functions based on the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain. Cross-linking of LAIR1 on human T cell clones results in inhibition of cytotoxicity only in T cell clones that lack CD28 and are able to spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of freshly isolated T cells, which is thought to be mainly due to "effector" T cells, can be inhibited by anti-LAIR1 mAb. Thus, LAIR1 functions as an inhibitory receptor not only on NK cells, but also on human T cells. This indicates that LAIR1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells.
- Meyaard L. et al., 1999, J Immunol. 162 (10): 5800-4.
- Meyaard L. et al., 2001, J Exp Med. 194 (1): 107-12.
- Xu M. et al., 2000, J Biol Chem. 275 (23): 17440-6.