LAIR1 Protein

Leukocyte-associated Ig-like receptor 1

LAIR1 Products

LAIR1 Protein, Recombinant

Molecule	Species	Description	Cat. No
LAIR1	Mouse	LAIR1 Protein, Recombinant	51030-M08H

LAIR1 cDNA Clone

Molecule	Species	Description	Cat. No
LAIR1	Human	LAIR1 cDNA Clone / ORF Clone	HG13257-G
LAIR1	Mouse	LAIR1 cDNA Clone / ORF Clone	MG51030-G
LAIR1	Rat	LAIR1 cDNA Clone / ORF Clone	RG80415-G

LAIR1 Related Areas

Immunology>>Adaptive Immunity>>T Cell>>T Cell Migration/Adhesion>> LAIR1

Immunology>>Adaptive Immunity >>B Cell>> LAIR1

LAIR1 Alternative Names

XXbac-BCX403H19.4, CD305, LAIR-1 [Homo sapiens]

5133400O11Rik, BB115266, D7Bwg0421e, Lair-1, mLair-1 [Mus musculus]

LAIR1 Background

Leukocyte associated Ig-like receptor-1 (LAIR1) is a surface molecule expressed on human mononuclear leukocytes that functions as an inhibitory receptor on human NK cells. In addition to NK cells, LAIR1 is expressed on T cells, B cells, macrophages, and dendritic cells. It is predicted to mediate inhibitory functions based on the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain. Cross-linking of LAIR1 on human T cell clones results in inhibition of cytotoxicity only in T cell clones that lack CD28 and are able to spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of freshly isolated T cells, which is thought to be mainly due to "effector" T cells, can be inhibited by anti-LAIR1 mAb. Thus, LAIR1 functions as an inhibitory receptor not only on NK cells, but also on human T cells. This indicates that LAIR1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells. 

LAIR1 Related Studies

1. Meyaard L, et al. (1999) Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells. J Immunol. 162 (10): 5800-4.
2. Meyaard L, et al. (2001) The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR). J Exp Med. 194 (1): 107-12.
3. Xu M, et al. (2000) Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells. J Biol Chem. 275 (23): 17440-6.