L1CAM Protein & Antibody (CD171, NCAM-L1)

L1 Cell Adhesion Molecule (Cluster of Differentiation 171, Neural Cell Adhesion Molecule L1)

L1CAM Products

L1CAM Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
L1CAM/CD171	Human	L1CAM/CD171/Fc Protein, Recombinant	10140-H03H
L1CAM/CD171	Human	L1CAM/CD171 Protein, Recombinant	10140-H08H

L1CAM Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human L1CAM/CD171	WB, ELISA	L1CAM/CD171 Antibody, Rabbit PAb	10140-RP01
Human L1CAM/CD171	WB, ELISA	L1CAM/CD171 Antibody, Rabbit PAb (Antigen Affinity Purified)	10140-RP02
Human L1CAM/CD171	WB, ELISA	CD171 / N-CAML1 / L1CAM Antibody	10140-R004
Human L1CAM/CD171	FCM	CD171 / N-CAML1 / L1CAM Antibody ( FITC )	10140-R014-F
Human L1CAM/CD171	ELISA	CD171 / N-CAML1 / L1CAM Antibody	10140-MM01

L1CAM cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
L1CAM/CD171	Human	Human CD171 / NCAM-L1 transcript variant 2 cDNA Clone / ORF Clone	HG10140-G
L1CAM/CD171	Mouse	Mouse L1CAM/CD171 cDNA Clone / ORF Clone	MG50835-G

L1CAM Related Areas

Neuroscience>>Synaptic Protein>>L1CAM/CD171

Stem Cell>>Neural Stem Cell (NSC)>>Neuronal Cell Markers>>L1CAM/CD171

Cancer>>Cancer Biomarkers>>L1CAM/CD171

Immunology>>Adaptive Immunity>>T Cell>>T Cell Migration/Adhesion>>L1CAM/CD171

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>L1CAM/CD171

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>L1CAM/CD171

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Neutrophils>>L1CAM/CD171

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Monocyte Markers>>L1CAM/CD171

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>T Cell Migration/Adhesion>>L1CAM/CD171

L1CAM Alternative Names

L1CAM, CD171, NCAM-L1, CAML1, HSAS, HSAS1, MASA, MIC5, N-CAML1, S10, SPG1

L1CAM Background

L1 cell adhesion molecule (L1CAM), also designated as CD171, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and in a variety of cancer cells, including some common types of human cancer. L1CAM interacts with a variety of ligands including axonin-1, CD9, neurocan and intergrins, and it has been revealed that the RGD motif in the sixth Ig domain of L1CAM is a binding site for integrins, thus important for nuclear signaling. Disruption of L1CAM function causes three X-linked neurological syndromes, i.e. hydrocephalus, MASA syndrome (mental retardation, aphasia, shuffling gait and adducted thumbs) and spastic paraplegia syndrome. Overexpression of L1CAM in normal and cancer cells increased motility, enhanced growth rate and promoted cell transformation and tumorigenicity. Recent work has identified L1CAM (CD171) as a novel marker for human carcinoma progression, and a candidate for anti-cancer therapy.

L1CAM Related Studies

1. Meier F, et al. (2006) The adhesion molecule L1 (CD171) promotes melanoma progression. Int J Cancer. 119(3): 549-55.
2. Gavert N, et al. (2008) L1-CAM in cancerous tissues. Expert Opin Biol Ther. 8(11): 1749-57.
3. Issa Y, et al. (2009) Enhanced L1CAM expression on pancreatic tumor endothelium mediates selective tumor cell transmigration. J Mol Med. 87(1): 99-112.
4. Weidle UH, et al. (2009) L1-CAM as a target for treatment of cancer with monoclonal antibodies. Anticancer Res. 29(12): 4919-31.
5. Raveh S, et al. (2009) L1 cell adhesion molecule (L1CAM) in invasive tumors. Cancer Lett. 282(2): 137-45.
6. Wolterink S, et al. (2010) Therapeutic antibodies to human L1CAM: functional characterization and application in a mouse model for ovarian carcinoma. Cancer Res. 70(6): 2504-15.