Kynureninase Protein

Kynureninase Products

Kynureninase Protein, Recombinant

Molecule	Species	Description	Cat. No
Kynureninase	Human	KYNU/Kynureninase Protein, Recombinant	10841-H08B
Kynureninase	Mouse	KYNU/Kynureninase Protein, Recombinant	50310-M08B

Kynureninase cDNA Clone

Molecule	Species	Description	Cat. No
Kynureninase	Human	Human Kynureninase cDNA Clone / ORF Clone	HG10841-M
Kynureninase	Mouse	Mouse Kynureninase cDNA Clone / ORF Clone	MG50310-M

Kynureninase Related Areas

Neuroscience>>Synaptic Protein>>Kynureninase

Kynureninase Alternative Names

Kynureninase, KYNU, OTTHUMP00000162647, OTTHUMP00000204304, OTTHUMP00000204305  [Homo sapiens]

Kynureninase, Kynu, RP23-303O15.1, 4432411A05Rik [Mus musculus]

Kynureninase Background

Kynureninase (KYNU), also known as L-kynurenine hydrolase), is a member of a large family of catalytically diverse but structurally homologous pyridoxal 5'-phosphate (PLP) dependent enzymes known as the aspartate aminotransferase superfamily or alpha-family. The Homo sapiens and other eukaryotic constitutive kynureninases preferentially catalyze the hydrolytic cleavage of 3-hydroxy-l-kynurenine to produce 3-hydroxyanthranilate and l-alanine, while l-kynurenine is the substrate of many prokaryotic inducible kynureninases. Kynureninase is one of the enzymes involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. kynureninase is in subgroup IVa of the aminotransferases, along with nifS, CsdB, and serine-pyruvate aminotransferase, which suggests that kynureninase has an aminotransferase fold.

Kynureninase Related Studies

1. Lima S, et al. (2007) Crystal structure of Homo sapiens kynureninase. Biochemistry. 46(10): 2735-44.
2. Momany C, et al. (2004) Three-dimensional structure of kynureninase from Pseudomonas fluorescens. Biochemistry. 43(5): 1193-203.
3. Toma S, et al. (1997) Cloning and recombinant expression of rat and human kynureninase. FEBS Lett. 408(1): 5-10.