KSP-Cadherin / Cadherin-16 Protein & Antibody (CDH16)

KSP-Cadherin / Cadherin-16 Products

KSP-Cadherin / Cadherin-16 Protein, Recombinant

Molecule	Species	Description	Cat. No
KSP-Cadherin/Cadherin-16/CDH16	Human	KSP-Cadherin/Cadherin-16/CDH16 Protein, Recombinant	10915-H08H

KSP-Cadherin / Cadherin-16 Antibody

Molecule	Application	Description	Cat. No
Human KSP-Cadherin/Cadherin-16/CDH16	ELISA	KSP-Cadherin/Cadherin-16/CDH16 Antibody, Mouse MAb	10915-MM09

KSP-Cadherin / Cadherin-16 cDNA Clone

Molecule	Species	Description	Cat. No
KSP-Cadherin/Cadherin-16/CDH16	Human	Homo sapiens KSP-Cadherin/Cadherin-16/CDH16 cDNA Clone	HG10915-M
KSP-Cadherin/Cadherin-16/CDH16	Mouse	KSP-Cadherin/Cadherin-16/CDH16 cDNA Clone / ORF Clone	MG50899-G
KSP-Cadherin/Cadherin-16/CDH16	Rat	CDH16 cDNA Clone / ORF Clone	RG80282-G

KSP-Cadherin / Cadherin-16 Related Areas

Immunology>>Adhesion Molecule>>Cadherin>>KSP-Cadherin/Cadherin-16/CDH16

KSP-Cadherin / Cadherin-16 Alternative Names

KSP-Cadherin, Cadherin-16, CDH16, UNQ695/PRO1340 [Homo sapiens]

KSP-Cadherin, Cadherin-16, Cdh16, kidney-specific cadherin [Mus musculus]

KSP-Cadherin / Cadherin-16 Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
E-Cadherin/CDH1/CD324	Human	E-Cadherin/CDH1 Protein, Recombinant
E-Cadherin/CDH1	Mouse	E-Cadherin/CDH1 Protein, Recombinant
N-Cadherin/CD325/CDH2	Human	N-Cadherin/CD325/CDH2 Protein, Recombinant
R-Cadherin/CDH4	Human	R-Cadherin/CDH4 Protein, Recombinant
VE-Cadherin/CD144/CDH5	Human	VE-Cadherin/CD114/Fc Protein, Recombinant
VE-Cadherin/CD144/CDH5	Mouse	VE-Cadherin/CD144/CDH5 Protein, Recombinant
Cadherin-6/K-Cadherin/CDH6	Human	Cadherin-6/K-Cadherin/CDH6 Protein, Recombinant
Cadherin-8/CDH8	Human	Cadherin-8/CDH8 Protein, Recombinant
Cadherin-12/CDH12	Human	Cadherin-12/CDH12 Protein, Recombinant
Cadherin-17/LI-cadherin	Human	Cadherin-17/LI-cadherin Protein, Recombinant

Antibody Products

Molecule	Applications	Description //For Detailed Info. and Price------CLICK!
Human E-Cadherin/CDH1/CD324	WB, ELISA	Mouse Monoclonal Antibody
Human E-Cadherin/CDH1/CD324	ELISA	Mouse Monoclonal Antibody
Human E-Cadherin/CDH1/CD324	WB, ELISA	Rabbit Polyclonal Antibody
Human E-Cadherin/CDH1/CD324	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human R-Cadherin/CDH4	WB, ELISA	R-Cadherin/CDH4 Antibody, Rabbit PAb
Human R-Cadherin/CDH4	WB, ELISA	R-Cadherin/CDH4 Antibody, Rabbit PAb (Antigen Affinity Purified)
Mouse VE-Cadherin/CD144/CDH5	WB, ELISA	Rabbit Polyclonal Antibody

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
E-Cadherin/CDH1/CD324	Human	Homo sapiens E-Cadherin/CDH1 cDNA Clone(NM_004360.3)
N-Cadherin/CD325/CDH2	Human	Homo sapiens N-Cadherin/CD325/CDH2 cDNA Clone(NM_001792.3)
P-Cadherin/CDH3	Human	Homo sapiens P-Cadherin/CDH3 cDNA Clone(NM_001793.4)
VE-Cadherin/CD144/CDH5	Human	Homo sapiens VE-Cadherin/CD144/CDH5 cDNA Clone(NM_001795.3)
VE-Cadherin/CD144/CDH5	Mouse	Mus musculus VE-Cadherin/CD114/CDH5 cDNA Clone
Cadherin-6/K-Cadherin/CDH6	Human	Homo sapiens Cadherin-6/K-Cadherin/CDH6 cDNA Clone(NM_004932.2)
Cadherin-8/CDH8	Human	Homo sapiens Cadherin-8/CDH8 cDNA Clone(NM_001796.2)
Cadherin-11/CDH11	Human	Homo sapiens Cadherin-11/CDH11 cDNA Clone(NM_001797.2)
Cadherin-12/CDH12	Human	Homo sapiens Cadherin-12/CDH12 cDNA Clone(NM_004061.3)
Cadherin-17/LI-cadherin	Human	Homo sapiens Cadherin-17/LI-cadherin/CDH17 cDNA Clone

KSP-Cadherin / Cadherin-16 Background

KSP-Cadherin/Cadherin-16 is a member of the cadherin superfamily, calcium-dependent, membrane-associated glycoproteins. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. KSP-Cadherin/Cadherin-16 can be detected at later stages of tubulogenesis during human renal development and in the distal tubules of adult kidneys, no expression was found by immunohistochemistry or Western blot analysis in RCC tumour tissues and several RCC cell lines. However, despite the lack of protein expression, mRNA synthesis of KSP-Cadherin/Cadherin-16 could be detected by reverse transcriptase-polymerase chain reaction analysis in all RCC tissues and most of the RCC cell lines studied, although at a reduced level. The loss of KSP-Cadherin/Cadherin-16 protein was only observed in the malignant part of the tumour kidneys, whereas in the normal part of the affected kidneys KSP-Cadherin/Cadherin-16 expression was clearly detected. These results indicate a downregulation of Ksp-cadherin in RCC and suggest a role for this cell adhesion molecule in tumour suppression.

KSP-Cadherin / Cadherin-16 Related Studies

1. Thomson RB, et al. (1999) Immunolocalization of Ksp-cadherin in the adult and developing rabbit kidney. Am J Physiol. 277 (1): 146-56.
2. Thedieck C, et al. (2005) Expression of Ksp-cadherin during kidney development and in renal cell carcinoma. Br J Cancer. 92(11): 2010-7.
3. Bai Y, et al. (2002) Regulation of kidney-specific Ksp-cadherin gene promoter by hepatocyte nuclear factor-1beta. Am J Physiol Renal Physiol. 283(4): 839-51.