Anti-Kininogen 1 Antibody

Cat: 50474-RP02
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Anti-Kininogen 1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Kininogen 1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse Kininogen 1
Immunogen
Recombinant Mouse KNG1 protein (Catalog#50474-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse KNG1 (rM KNG1; Catalog#50474-M08H; NP_001095882.1; Glu 21-Ser 480). KNG1 specific IgG was purified by mouse KNG1 affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Kininogen 1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Kininogen 1 Antibody Alternative Names
Anti-Kng Antibody
Kininogen 1 Background Information

Kininogen-1, also known as high molecular weight kininogen, williams-Fitzgerald-Flaujeac factor, Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, KNG1 and BDK, is a secreted protein which contains three cystatin domains. Kininogen-1 / KNG1 is a protein from the blood coagulation system as well as the kinin-kallikrein system. It is a protein that adsorbs to the surface of biomaterials that come in contact with blood. Kininogen-1 / KNG1 circulates throughout the blood and quickly adsorbs to the material surfaces. Kininogen-1 / KNG1 is one of the early participants of the intrinsic pathway of coagulation, together with Factor XII (Hageman factor) and prekallikrein. Kininogen-1 / KNG1 is one of the kininogens, a class of proteins. As with many other coagulation proteins, the protein was initially named after the patients in whom deficiency was first observed. When the clinical data were combined, it turned out that all patients, in fact, had a deficiency of the same protein. Defects in KNG1 are the cause of high molecular weight kininogen deficiency (HMWK deficiency) which is an autosomal recessive coagulation defect. Patients with HWMK deficiency do not have a hemorrhagic tendency, but they exhibit abnormal surface-mediated activation of fibrinolysis.

Full Name
kininogen 1
References
  • Ohkubo I., et al.,(1984), Isolation of a human cDNA for alpha 2-thiol proteinase inhibitor and its identity with low molecular weight kininogen. Biochemistry 23:5691-5697.
  • Takagaki Y., et al., (1985), Cloning and sequence analysis of cDNAs for human high molecular weight and low molecular weight prekininogens. Primary structures of two human prekininogens.J. Biol. Chem. 260:8601-8609.
  • Ota T., et al.,(2004), Complete sequencing and characterization of 21,243 full-length human cDNAs.Nat. Genet. 36:40-45.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Kininogen 1 Antibody Rabbit Monoclonal ELISA 50474-R006
    Anti-Kininogen 1 Antibody Rabbit Polyclonal ELISA 50474-RP01
    Anti-Kininogen 1 Antibody Rabbit Polyclonal ELISA 50474-T16
    Anti-Kininogen 1 Antibody Mouse Monoclonal ELISA(Cap) 10529-MM06
    Anti-Kininogen 1 Antibody Rabbit Polyclonal ELISA 10529-RP01
    Anti-Kininogen 1 Antibody Mouse Monoclonal ELISA 10529-MM10
    Anti-Kininogen 1 Antibody Rabbit Polyclonal ELISA 10529-T16
    Anti-Kininogen 1 Antibody Mouse Monoclonal ELISA(Det) 10529-MM09
    Anti-Kininogen 1 Antibody Rabbit Polyclonal ELISA 10529-RP02
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