KLRB1F / NKR-P1F Protein

Killer cell lectin-like receptor subfamily B member 1F

KLRB1F / NKR-P1F Products

KLRB1F / NKR-P1F Protein, Recombinant

Molecule	Species	Description	Cat. No
KLRB1F/NKR-P1F	Mouse	KLRB1F/NKR-P1F Protein, Recombinant	50815-M01H

KLRB1F / NKR-P1F cDNA Clone

Molecule	Species	Description	Cat. No
KLRB1F/NKR-P1F	Mouse	Mouse KLRB1F cDNA Clone / ORF Clone	MG50815-G

KLRB1F / NKR-P1F Alternative Names

Klrb1f, A630024B12Rik, MGC130065, MGC130066, Nkr-p1f, Nkrp1-f, Nkrp1f [Mus musculus]

KLRB1F / NKR-P1F Background

KLRB1F (Killer cell lectin-like receptor subfamily B member 1F), also known as NKR-P1F (Natural killer cell surface protein NKR-P1F), which was found to be expressed on the surface of most or all NK cells and appeared to be expressed in a highly NK-specific manner with no significant expression on a variety of fresh and cultured T and B lymphocytes. The rat and mouse KLRB1F/NKR-P1F and NKR-P1G receptors demonstrate a striking, cross-species conservation of specificity for Clr ligands. The conserved KLRB1F/NKR-P1F and NKR-P1G receptors function as promiscuous receptors for a rapidly evolving family of Clr ligands in rodent NK cells. NKRP1f-expressing antigen presenting cells (APC) enhance B7.1/CD28-mediated costimulation for T cell proliferation through interaction with OCILRP2/Clr-g.

KLRB1F / NKR-P1F Related Studies

1. Kveberg L, et al. (2011) Phylogenetic and functional conservation of the NKR-P1F and NKR-P1G receptors in rat and mouse. Immunogenetics. 63(7): 429-36.
2. Aust JG, et al. (2009) The expression and function of the NKRP1 receptor family in C57BL/6 mice. J Immunol. 183(1): 106-16.
3. Tian W, et al. (2005) C-type lectin OCILRP2/Clr-g and its ligand NKRP1f costimulate T cell proliferation and IL-2 production. Cell Immunol. 234(1): 39-53.
4. Plougastel B, et al. (2001) Analysis of a 1-Mb BAC contig overlapping the mouse Nkrp1 cluster of genes: cloning of three new Nkrp1 members, Nkrp1d, Nkrp1e, and Nkrp1f. Immunogenetics. 53(7): 592-8.