Anti-Kallikrein 8 Antibody

Cat: 11820-RP02
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Anti-Kallikrein 8 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Kallikrein 8 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Kallikrein 8
Immunogen
Recombinant Human KLK8 / Kallikrein 8 protein (Catalog#11820-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human KLK8 / Kallikrein 8 (rh KLK8 / Kallikrein 8; Catalog#11820-H08H; O60259-1; Met 1-Gly 260). KLK8 / Kallikrein 8 specific IgG was purified by Human KLK8 / Kallikrein 8 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Kallikrein 8 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Kallikrein 8 Antibody Alternative Names
Anti-HNP Antibody;Anti-NP Antibody;Anti-NRPN Antibody;Anti-PRSS19 Antibody;Anti-TADG14 Antibody
Kallikrein 8 Background Information

Kallikrein-8, also known as Neuropsin, Serine protease 19, Serine protease TADG-14, Tumor-associated differentially expressed gene 14 protein and KLK8, is a secreted protein which belongs to the peptidase S1 family and Kallikrein subfamily. It is a serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Kallikrein-8 / KLK8 plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway. It regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. It is involved in skin desquamation and keratinocyte proliferation and plays a role in the secondary phase of pathogenesis following spinal cord injury. It also cleaves L1CAM in response to increased neural activity. It induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Kallikrein-8 / KLK8 is expressed at high levels in serum, ascites fluid and tumor cytosol of advanced stage ovarian cancer patients and may serve as a marker of ovarian cancer. Kallikrein-8 / KLK8 may have potential clinical value for disease diagnosis or prognosis and it may also be a useful therapeutic target.

Full Name
kallikrein-related peptidase 8
References
  • Yoshida S., et al.,(1998), Sequence analysis and expression of human neuropsin cDNA and gene. Gene 213:9-16.
  • Underwood L.J., et al., (1999), Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma.Cancer Res. 59:4435-4439.
  • Mitsui S., et al.,(1999), A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain.Eur. J. Biochem. 260:627-634.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Kallikrein 8 Antibody Rabbit Monoclonal ELISA 11820-R038
    Anti-Kallikrein 8 Antibody Rabbit Polyclonal ELISA 11820-RP01
    Anti-Kallikrein 8 Antibody Rabbit Monoclonal WB 11820-R140
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