Anti-Kallikrein 7 Antibody (Rabbit Polyclonal antibody) General Information
Anti-Kallikrein 7 Antibody
Reacts with: Human
Human Kallikrein 7
Recombinant Human KLK7 protein (Catalog#10416-H08H)
Produced in rabbits immunized with purified, recombinant Human KLK7 (rh KLK7; Catalog#10416-H08H; NP_005037.1; Met 1-Arg 253). KLK7 specific IgG was purified by human KLK7 affinity chromatography
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Kallikrein 7 Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-Kallikrein 7 Antibody (Rabbit Polyclonal antibody) Images
Immunochemical staining of human KLK7 in human skin with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).Positive staining was localized to keratinocytes in the epidermis.
Anti-Kallikrein 7 Antibody Alternative Names
Anti-hK7 Antibody;Anti-PRSS6 Antibody;Anti-SCCE Antibody
Kallikrein 7 Background Information
Kallikrein-7, also known as kallikrein-related peptidase 7, Stratum corneum chymotryptic enzyme, Serine protease 6, KLK7, and PRSS6, is a secreted protein which belongs to the peptidase S1 family and Kallikrein subfamily. Members of the Kallikrein family are involved in various malignancies such as prostate (PSA, KLK2, KLK15), ovarian (KLK4, KLK5, KLK6, KLK8, KLK10), and breast cancer (KLK10, KLK13, KLK14). Kallikrein-7 / KLK7 appears to be increased in ovarian cancer and higher KLK7 expression in ovarian cancer tissue is associated with poorer prognosis of ovarian cancer patients. Kallikrein-7 / KLK7 is abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Kallikrein-7 / KLK7 is up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at the protein level). It was significantly associated with shorter overall survival (OS) and disease-free survival (DFS). Kallikrein-7 / KLK7 may catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. KLK7 also plays a role in the activation of precursors to inflammatory cytokines.
kallikrein-related peptidase 7
Hansson L., et al.,(1994), Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase. J. Biol. Chem. 269:19420-19426.Yousef G.M., et al., (2000), The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family -- genomic characterization, mapping, tissue expression and hormonal regulation.Gene 254:119-128.Gan L., et al.,(2000), Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.Gene 257:119-130.