KLK6 Protein

kallikrein-related peptidase 6

KLK6 / Klk7 Products

KLK6 / Klk7 Protein, Recombinant

Molecule	Species	Description	Cat. No
KLK6 / Klk7	Human	KLK6 / Klk7 Protein, Recombinant (His Tag)	12142-H08H

KLK6 / Klk7 cDNA Clone

Molecule	Species	Description	Cat. No
KLK6 / Klk7	Mouse	Mouse KLK6 / Klk7 cDNA Clone / ORF Clone	MG50255-M
KLK6 / Klk7	Human	Human KLK6 / Klk7 cDNA Clone / ORF Clone	HG12142-G

KLK6 / Klk7 Related Areas

Cancer>>Angiogenesis>>Kallikrein>>KLK6 / Klk7

Cancer>>Cancer Biomarkers>>KLK6 / Klk7

KLK6 / Klk7 Alternative Names

Bssp, Klk7, PRSS18, PRSS9, SP59, hK6, kallikrein-6, neurosin, protease M, serine protease 18, serine protease 9, zyme [Homo sapiens]

Bssp, Klk29, MSP, Prss18, Prss9, neurosin, brain serine protease, kallikrein 29, kallikrein 6, myelencephalon-specific protease, myofibril-bound protease, protease M, protease, serine, 18, protease, serine, 9 [Mus musculus]

KLK6 / Klk7 Background

KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. KLK6 degrades alpha-synuclein and prevents its polymerization, indicating that KLK6 may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. Klk7 may be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.

KLK6 / Klk7 Related Studies

1. Krenzer S, et al. (2011) Expression and function of the kallikrein-related peptidase 6 in the human melanoma microenvironment. J Invest Dermatol. 131(11):2281-8.
2. Nathalie HV, et al. (2009) High kallikrein-related peptidase 6 in non-small cell lung cancer cells: an indicator of tumour proliferation and poor prognosis. J Cell Mol Med. 13(9B):4014-22.
3. Kim JT, et al. (2011) Up-regulation and clinical significance of serine protease kallikrein 6 in colon cancer. Cancer. 117(12):2608-19.
4. Scarisbrick IA, et al. (2011) Functional role of kallikrein 6 in regulating immune cell survival. PLoS One. 6(3):e18376.